ExoticRx · exoticrx.com/drugs/lipid-emulsion-ile-20
US brand names:Intralipid, ClinOleic
Lipid Emulsion (ILE) 20% is dosed at 1.5 ml/kg IV Bolus 1min, CRI 0.25ml/kg/min x30-60m in dogs, per Robben JH, Dijkman MA. Lipid therapy for intoxications. Vet Clin North Am Small Animal Pract. 2017;47(2):435-450. doi:10.1016/j.cvsm.2016.10.018 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.795 (2026-08-01).. Verify against current literature before clinical use.
Creates a lipid sink in plasma that sequesters lipophilic drugs away from target tissues. May also enhance mitochondrial energy production in cardiac tissue.
For local anesthetic systemic toxicity (LAST), permethrin toxicity, and other lipophilic drug overdoses. Pancreatitis risk. Interferes with lab tests. Use 20% emulsion only.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Lipid Emulsion (ILE) 20% CRI dose rules from the ExoticRx formulary. Verify against current literature before clinical use; CRI rates differ from bolus dosing and route, dilution, and monitoring matter. Sign in for the complete per-species CRI protocol set.
| Species | Route | Rate | Indication | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1.5 ml/kgBolus 1min, CRI 0.25ml/kg/min x30-60m | Local anesthetic systemic toxicity (LAST)/Lipophilic drug overdose | Moderate | Robben JH, Dijkman MA. Lipid therapy for intoxications. Vet Clin North Am Small Animal Pract. 2017;47(2):435-450. doi:10.1016/j.cvsm.2016.10.018 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.795 (2026-08-01). |
| Cat (Domestic) | IV | 1.5–2 ml/kgBolus 1min, CRI 0.25ml/kg/min x30-60m | Permethrin toxicity/Lipophilic drug overdose | Moderate | Robben JH, Dijkman MA. Lipid therapy for intoxications. Vet Clin North Am Small Animal Pract. 2017;47(2):435-450. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.795 (2026-08-01). |
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1.5 ml/kg | Bolus 1min, CRI 0.25ml/kg/min x30-60m | Moderate | Robben JH, Dijkman MA. Lipid therapy for intoxications. Vet Clin North Am Small Animal Pract. 2017;47(2):435-450. doi:10.1016/j.cvsm.2016.10.018 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.795 (2026-08-01). |
| Cat (Domestic) | IV | 1.5–2 ml/kg | Bolus 1min, CRI 0.25ml/kg/min x30-60m | Moderate | Robben JH, Dijkman MA. Lipid therapy for intoxications. Vet Clin North Am Small Animal Pract. 2017;47(2):435-450. doi:10.1016/j.cvsm.2016.10.018 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.795 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
Local anesthetic systemic toxicity (LAST)/Lipophilic drug overdose
Permethrin toxicity/Lipophilic drug overdose