ExoticRx · exoticrx.com/drugs/methenamine-hippurate
US brand names:Hiprex, Urex
Methenamine Hippurate is dosed at 10–20 mg/kg PO q12h in dogs, per Greene CE. Infectious Diseases of the Dog and Cat. Elsevier Health Sciences; 2013. Distributed by John Wiley & Sons, Inc. doi:10.1016/c2014-0-03934-2 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.876 (2026-08-01).. Verify against current literature before clinical use.
Hydrolyzed to formaldehyde in acidic urine (pH <6.0), which is bactericidal. Hippuric acid component helps acidify urine.
Requires acidic urine pH (<6.0) for efficacy. Ineffective in alkaline urine. Avoid with sulfonamides (insoluble precipitate). Not effective for upper UTI.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 10–20 mg/kg | q12h | Moderate | Greene CE. Infectious Diseases of the Dog and Cat. Elsevier Health Sciences; 2013. Distributed by John Wiley & Sons, Inc. doi:10.1016/c2014-0-03934-2 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.876 (2026-08-01). |
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