Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Methenamine Hippurate is dosed at 10–20 mg/kg PO q12h in dogs, per Greene CE. Infectious Diseases of the Dog and Cat. Elsevier Health Sciences; 2013. Distributed by John Wiley & Sons, Inc. doi:10.1016/c2014-0-03934-2 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.876 (2026-08-01). — Plumb's 10th ed (held) printed p.848, Methenamine monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Methenamine Hippurate is used in dogs for Recurrent UTI prevention. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Methenamine Hippurate in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Hiprex, Urex
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 10–20 mg/kg | q12h | Long-term maintenance | Recurrent UTI prevention | Moderate | Greene CE. Infectious Diseases of the Dog and Cat. Elsevier Health Sciences; 2013. Distributed by John Wiley & Sons, Inc. doi:10.1016/c2014-0-03934-2 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.876 (2026-08-01). — Plumb's 10th ed (held) printed p.848, Methenamine monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/animal) | Route | Source | As printed |
|---|---|---|---|
| 500 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.534 | • Methenamine hippurate: 500 mg/dog q12h PO. |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 10–20 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.534 | • Methenamine mandelate (if available): 10-20 mg/kg q8-12h PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Hydrolyzed to formaldehyde in acidic urine (pH <6.0), which is bactericidal. Hippuric acid component helps acidify urine.
Requires acidic urine pH (<6.0) for efficacy. Ineffective in alkaline urine. Avoid with sulfonamides (insoluble precipitate). Not effective for upper UTI.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Methenamine Hippurate dose range in dogs, with cited source references: PO 10–20 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Methenamine Hippurate in dogs: PO.
Cited course lengths for Methenamine Hippurate in dogs include: Long-term maintenance. Duration depends on the indication — match it to the specific dose rule in the table above.
Methenamine Hippurate is indicated in dogs for: Recurrent UTI prevention.
These are general warnings for Methenamine Hippurate across species; consult the dog dosing table above for species-specific guidance. Requires acidic urine pH (<6.0) for efficacy. Ineffective in alkaline urine. Avoid with sulfonamides (insoluble precipitate). Not effective for upper UTI.
Why a species-specific page? Methenamine Hippurate pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.