ExoticRx · exoticrx.com/drugs/methylene-blue
US brand names:ProvayBlue
Methylene Blue is dosed at 1–1.5 mg/kg IV IV over 15 min, may repeat once in dogs, per Harvey J. Toxic hemolytic anemias. Presented at: Proceedings: ACVIM; 2006. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.887 (2026-08-01).. Verify against current literature before clinical use.
Reduced to leucomethylene blue by NADPH-methemoglobin reductase, which then reduces methemoglobin back to functional hemoglobin.
Specific antidote for methemoglobinemia (acetaminophen toxicity in cats, nitrate/nitrite poisoning). TOXIC TO CATS at high doses (causes Heinz body anemia). Paradoxically causes methemoglobinemia at very high doses.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1–1.5 mg/kg | IV over 15 min, may repeat once | Moderate | Harvey J. Toxic hemolytic anemias. Presented at: Proceedings: ACVIM; 2006. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.887 (2026-08-01). |
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