Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Methylene Blue is dosed at 1–1.5 mg/kg IV IV over 15 min, may repeat once in dogs, per Harvey J. Toxic hemolytic anemias. Presented at: Proceedings: ACVIM; 2006. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.887 (2026-08-01). — Plumb's 10th ed (held) printed p.860, Methylene Blue monograph spanning p.859-860; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Methylene Blue is used in dogs for Methemoglobinemia. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Methylene Blue in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: ProvayBlue
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 1–1.5 mg/kg | IV over 15 min, may repeat once | 1-2 doses | Methemoglobinemia |
| Harvey J. Toxic hemolytic anemias. Presented at: Proceedings: ACVIM; 2006. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.887 (2026-08-01). — Plumb's 10th ed (held) printed p.860, Methylene Blue monograph spanning p.859-860; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 1.5 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.543 | • 1.5 mg/kg IV once slowly. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Reduced to leucomethylene blue by NADPH-methemoglobin reductase, which then reduces methemoglobin back to functional hemoglobin.
Specific antidote for methemoglobinemia (acetaminophen toxicity in cats, nitrate/nitrite poisoning). TOXIC TO CATS at high doses (causes Heinz body anemia). Paradoxically causes methemoglobinemia at very high doses.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Methylene Blue dose range in dogs, with cited source references: IV 1–1.5 mg/kg IV over 15 min, may repeat once. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Methylene Blue in dogs: IV.
Cited course lengths for Methylene Blue in dogs include: 1-2 doses. Duration depends on the indication — match it to the specific dose rule in the table above.
Methylene Blue is indicated in dogs for: Methemoglobinemia.
These are general warnings for Methylene Blue across species; consult the dog dosing table above for species-specific guidance. Specific antidote for methemoglobinemia (acetaminophen toxicity in cats, nitrate/nitrite poisoning). TOXIC TO CATS at high doses (causes Heinz body anemia). Paradoxically causes methemoglobinemia at very high doses.
Why a species-specific page? Methylene Blue pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.