Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Methylene Blue is used in dog for Methemoglobinemia. Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Methylene Blue in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: ProvayBlue
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 1–1.5 mg/kg | IV over 15 min, may repeat once | 1-2 doses | Methemoglobinemia | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Reduced to leucomethylene blue by NADPH-methemoglobin reductase, which then reduces methemoglobin back to functional hemoglobin.
Specific antidote for methemoglobinemia (acetaminophen toxicity in cats, nitrate/nitrite poisoning). TOXIC TO CATS at high doses (causes Heinz body anemia). Paradoxically causes methemoglobinemia at very high doses.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Methylene Blue pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.