Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Methylene Blue is dosed at 1–1.5 mg/kg IV IV over 15 min, may repeat once in dogs, per Harvey J. Toxic hemolytic anemias. Presented at: Proceedings: ACVIM; 2006. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.887 (2026-08-01).. Methylene Blue is used in dogs for Methemoglobinemia. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Methylene Blue in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: ProvayBlue
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 1–1.5 mg/kg | IV over 15 min, may repeat once | 1-2 doses | Methemoglobinemia | Moderate | Harvey J. Toxic hemolytic anemias. Presented at: Proceedings: ACVIM; 2006. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.887 (2026-08-01). |
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Reduced to leucomethylene blue by NADPH-methemoglobin reductase, which then reduces methemoglobin back to functional hemoglobin.
Specific antidote for methemoglobinemia (acetaminophen toxicity in cats, nitrate/nitrite poisoning). TOXIC TO CATS at high doses (causes Heinz body anemia). Paradoxically causes methemoglobinemia at very high doses.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Methylene Blue dose range in dogs, with cited source references: IV 1–1.5 mg/kg IV over 15 min, may repeat once. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Methylene Blue in dogs: IV.
Cited course lengths for Methylene Blue in dogs include: 1-2 doses. Duration depends on the indication — match it to the specific dose rule in the table above.
Methylene Blue is indicated in dogs for: Methemoglobinemia.
These are general warnings for Methylene Blue across species; consult the dog dosing table above for species-specific guidance. Specific antidote for methemoglobinemia (acetaminophen toxicity in cats, nitrate/nitrite poisoning). TOXIC TO CATS at high doses (causes Heinz body anemia). Paradoxically causes methemoglobinemia at very high doses.
Why a species-specific page? Methylene Blue pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.