ExoticRx · exoticrx.com/drugs/methylprednisolone-acetate-injectable
US brand names:Depo-Medrol
Methylprednisolone Acetate Injectable is dosed at 1 mg/kg IM Once; may repeat in 2-6 weeks if needed in dogs, per Papich, Saunders Handbook of Veterinary Drugs 4th ed, printed p.519 (corpus 547), Methylprednisolone, Small Animal Dosage, Dogs - the only retrieved page printing a canine mg/kg IM acetate dose; plumb printed p.865 (corpus 892) for the mg/dog label range. Verify against current literature before clinical use.
Depot formulation providing prolonged glucocorticoid effect lasting 2-6 weeks. Suppresses inflammation and immune-mediated conditions.
Prolonged adrenal suppression. Cannot titrate dose once injected. Risk of iatrogenic Cushing's with repeated use. Diabetogenic in cats.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IM | 1 mg/kg | Once; may repeat in 2-6 weeks if needed | Strong | Papich, Saunders Handbook of Veterinary Drugs 4th ed, printed p.519 (corpus 547), Methylprednisolone, Small Animal Dosage, Dogs - the only retrieved page printing a canine mg/kg IM acetate dose; plumb printed p.865 (corpus 892) for the mg/dog label range |
| Cat (Domestic) | IM | 2–5 mg/kg | Once; may repeat q4-8 weeks if needed | Weak | BSAVA Small Animal Formulary 10th Ed, Part A - Canine and Feline, p.260 (corpus PDF p.276), Methylprednisolone, DOSES, Cats — 1-2 mg/kg i.m. depot q1-3wk (asthma) and 5 mg/kg i.m. depot (inflammation/flea allergy); q4-8 week interval printed verbatim in Veterinary Pharmacology & Therapeutics Box 48.2 (PDF p.1335); 5.5 mg/kg IM in Muller & Kirk p.147 — SOURCE EDITION: BSAVA Small Animal Formulary, Part A — Canine and Feline — ISBN 9781910443705, https://openlibrary.org/isbn/9781910443705; Veterinary Pharmacology and Therapeutics — ISBN 9781118855829, ; Muller & Kirk's Small Animal Dermatology — ISBN 9781416000280, — CEILING: FDA-approved label, methylprednisolone acetate — "The average dose is 10 mg/cat (NOT mg/kg) IM with a range up to 20 mg/cat (NOT mg/kg)." |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.