Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Mibolerone is dosed at 0.0026–0.005 mg/kg PO q24h in dogs, per Papich Handbook of Veterinary Drugs, 5th Ed, printed p.528 (corpus p.556), Mibolerone, Small Animal Dosage, Dogs — EDITION CORRECTED 2026-08-07: this citation named the 5th edition, which is not held. The page locator resolves in the 4th ed (2016), the copy actually consulted, and that page names the drug; the reference is to the 4th. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855. Mibolerone is used in dogs for Estrus suppression. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Mibolerone in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Cheque Drops
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.0026–0.005 mg/kg | q24h | Daily continuous; begin at least 30 days before expected estrus; max 24 months | Estrus suppression | Weak | Papich Handbook of Veterinary Drugs, 5th Ed, printed p.528 (corpus p.556), Mibolerone, Small Animal Dosage, Dogs — EDITION CORRECTED 2026-08-07: this citation named the 5th edition, which is not held. The page locator resolves in the 4th ed (2016), the copy actually consulted, and that page names the drug; the reference is to the 4th. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mcg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2.6–5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.556 | • 2.6-5 mcg/kg/day PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Synthetic androgen that suppresses estrus by inhibiting LH release from the anterior pituitary. Also has anabolic and progestational activity.
Hepatotoxic with prolonged use. Virilization of female animals. Do NOT use in cats (hepatotoxicity), Bedlington Terriers, or pregnant animals. Discontinued but still used.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Mibolerone dose range in dogs, with cited source references: PO 0.0026–0.005 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Mibolerone in dogs: PO.
Cited course lengths for Mibolerone in dogs include: Daily continuous; begin at least 30 days before expected estrus; max 24 months. Duration depends on the indication — match it to the specific dose rule in the table above.
Mibolerone is indicated in dogs for: Estrus suppression.
These are general warnings for Mibolerone across species; consult the dog dosing table above for species-specific guidance. Hepatotoxic with prolonged use. Virilization of female animals. Do NOT use in cats (hepatotoxicity), Bedlington Terriers, or pregnant animals. Discontinued but still used.
Why a species-specific page? Mibolerone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.