Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Aglepristone is dosed at 10 mg/kg SC Days 1, 2, and 8 (or days 1 and 2 for mismating) in dogs, per Fieni F. Clinical evaluation of the use of aglepristone, with or without cloprostenol, to treat cystic endometrial hyperplasia-pyometra complex in bitches. Theriogenology. 2006;66(6-7):1550-1556. doi:10.1016/j.theriogenology.2006.02.009; ALIZIN - aglepristone solution for injection [UK Datasheet for dogs]. Virbac Limited; 2009. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.46 (2026-08-01). — Plumb's 10th ed (held) printed p.19, Aglepristone monograph spanning p.18-19; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Aglepristone is used in dogs for Pregnancy termination/Closed pyometra. Routes documented in dogs: SC. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Aglepristone in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Alizin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| SC | 10 mg/kg | Days 1, 2, and 8 (or days 1 and 2 for mismating) | 3 injections (days 1, 2, 8) for pyometra; 2 injections (days 1, 2) for mismating | Pregnancy termination/Closed pyometra | Strong | Fieni F. Clinical evaluation of the use of aglepristone, with or without cloprostenol, to treat cystic endometrial hyperplasia-pyometra complex in bitches. Theriogenology. 2006;66(6-7):1550-1556. doi:10.1016/j.theriogenology.2006.02.009; ALIZIN - aglepristone solution for injection [UK Datasheet for dogs]. Virbac Limited; 2009. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.46 (2026-08-01). — Plumb's 10th ed (held) printed p.19, Aglepristone monograph spanning p.18-19; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 10 | SC | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.24 | 10 mg/kg s.c. on days 1, 2 and 7. Additional doses may be given on days 14 and 21 if there is an i |
| 10 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.40 | • Terminate pregnancy: Two doses of • Treatment of pyometra: 10 mg/kg |
| 10 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.40 | 10 mg/kg (0.33 mL/kg) SQ once SQ, on days 1, 2, 7, and 14. |
| Dose (ml/kg) | Route | Source | As printed |
|---|
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Competitive progesterone receptor antagonist with high affinity. Blocks progesterone action on the uterus, terminating pregnancy or treating pyometra.
Pain at injection site. Not available in the US. Used for pregnancy termination and closed pyometra in Europe. Monitor for uterine discharge.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Aglepristone dose range in dogs, with cited source references: SC 10 mg/kg Days 1, 2, and 8 (or days 1 and 2 for mismating). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Aglepristone in dogs: SC.
Cited course lengths for Aglepristone in dogs include: 3 injections (days 1, 2, 8) for pyometra; 2 injections (days 1, 2) for mismating. Duration depends on the indication — match it to the specific dose rule in the table above.
Aglepristone is indicated in dogs for: Pregnancy termination/Closed pyometra.
These are general warnings for Aglepristone across species; consult the dog dosing table above for species-specific guidance. Pain at injection site. Not available in the US. Used for pregnancy termination and closed pyometra in Europe. Monitor for uterine discharge.
Why a species-specific page? Aglepristone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 0.33 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.40 | 10 mg/kg (0.33 mL/kg) SQ once SQ, on days 1, 2, 7, and 14. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.