ExoticRx · exoticrx.com/drugs/aglepristone
US brand names:Alizin
Aglepristone is dosed at 10 mg/kg SC q24h x 2 treatments in dwarf hamsters, per 47. Ewringmann A, Gloeckner B. Leitsymptome bei Hamster, Ratte, Maus und Rennmaus, Enke, Stuttgart, Germany; 2014. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.798 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.7 (Miscellaneous Agents Used in Rodents). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.
Competitive progesterone receptor antagonist with high affinity. Blocks progesterone action on the uterus, terminating pregnancy or treating pyometra.
Pain at injection site. Not available in the US. Used for pregnancy termination and closed pyometra in Europe. Monitor for uterine discharge.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Dwarf Hamster drugsAll Gerbil drugsAll Guinea Pig drugsAll Pet Rat drugsAll Syrian Hamster drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 7 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | SC | 10 mg/kg | Days 1, 2, and 8 (or days 1 and 2 for mismating) | Strong | Fieni F. Clinical evaluation of the use of aglepristone, with or without cloprostenol, to treat cystic endometrial hyperplasia-pyometra complex in bitches. Theriogenology. 2006;66(6-7):1550-1556. doi:10.1016/j.theriogenology.2006.02.009; ALIZIN - aglepristone solution for injection [UK Datasheet for dogs]. Virbac Limited; 2009. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.46 (2026-08-01). — Plumb's 10th ed (held) printed p.19, Aglepristone monograph spanning p.18-19; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Cat (Domestic) | SC | 10–15 mg/kg | Days 1 and 2 |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
| Georgiev P, Wehrend A. Mid-gestation pregnancy termination by the progesterone antagonist aglepristone in queens. Theriogenology. 2006;65(7):1401-1406. / Fieni F, Martal J, Marnet PG, Siliart B, Guittot F. Clinical, biological and hormonal study of mid-pregnancy termination in cats with aglepristone. Theriogenology. 2006;66(6-7):1721-1728. doi:10.1016/j.theriogenology.2005.08.011 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.46 (2026-08-01). — Plumb's 10th ed (held) printed p.19, Aglepristone monograph spanning p.18-19; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |