ExoticRx · exoticrx.com/drugs/aglepristone
US brand names:Alizin
Aglepristone is dosed at 10 mg/kg IM, SC on day 1, 2, and 8 in guinea pigs, per Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.798 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.7 (Miscellaneous Agents Used in Rodents). Verify against current literature before clinical use.
Competitive progesterone receptor antagonist with high affinity. Blocks progesterone action on the uterus, terminating pregnancy or treating pyometra.
Pain at injection site. Not available in the US. Used for pregnancy termination and closed pyometra in Europe. Monitor for uterine discharge.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Dwarf Hamster drugsAll Gerbil drugsAll Guinea Pig drugsAll Pet Rat drugsAll Syrian Hamster drugs
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A dog/cat sample is shown here. Cited dosing for all 7 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | SC | 10 mg/kg | Days 1, 2, and 8 (or days 1 and 2 for mismating) | Strong | Fieni F. Clinical evaluation of the use of aglepristone, with or without cloprostenol, to treat cystic endometrial hyperplasia-pyometra complex in bitches. Theriogenology. 2006;66(6-7):1550-1556. doi:10.1016/j.theriogenology.2006.02.009; ALIZIN - aglepristone solution for injection [UK Datasheet for dogs]. Virbac Limited; 2009. — Plumb's 10th ed printed p.19, Aglepristone monograph spanning p.18-19. |
| Cat (Domestic) | SC | 10–15 mg/kg | Days 1 and 2 | Moderate | Georgiev P, Wehrend A. Mid-gestation pregnancy termination by the progesterone antagonist aglepristone in queens. Theriogenology. 2006;65(7):1401-1406. / Fieni F, Martal J, Marnet PG, Siliart B, Guittot F. Clinical, biological and hormonal study of mid-pregnancy termination in cats with aglepristone. Theriogenology. 2006;66(6-7):1721-1728. — Plumb's 10th ed printed p.19, Aglepristone monograph spanning p.18-19. |
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