ExoticRx · exoticrx.com/drugs/medroxyprogesterone-acetate
US brand names:Depo-Provera, Provera
Medroxyprogesterone Acetate is dosed at 2–5 mg/kg SC Single injection during anestrus in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.815, Medroxyprogesterone monograph spanning p.815-816; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.816, Medroxyprogesterone monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Verify against current literature before clinical use.
Synthetic progestin that suppresses gonadotropin secretion, inhibiting ovulation and estrus. Also used for behavioral modification and dermatologic conditions.
Increased risk of pyometra, mammary neoplasia, diabetes mellitus, and adrenocortical suppression. Use spaying as preferred alternative. Not for long-term use.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | SC | 2–5 mg/kg | Single injection during anestrus | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.815, Medroxyprogesterone monograph spanning p.815-816; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.816, Medroxyprogesterone monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Cat (Domestic) | SC | 2–5 mg/kg | Single injection | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.815, Medroxyprogesterone monograph spanning p.815-816; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.816, Medroxyprogesterone monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
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