Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Medroxyprogesterone Acetate is dosed at 2–5 mg/kg SC Single injection during anestrus in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.815, Medroxyprogesterone monograph spanning p.815-816; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.816, Medroxyprogesterone monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Medroxyprogesterone Acetate is used in dogs for Estrus suppression. Routes documented in dogs: SC. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Medroxyprogesterone Acetate in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Depo-Provera, Provera
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| SC | 2–5 mg/kg | Single injection during anestrus | Single injection; provides 4-6 months estrus suppression | Estrus suppression | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.815, Medroxyprogesterone monograph spanning p.815-816; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — figure located 2026-08-05 at Plumb's 10th ed printed p.816, Medroxyprogesterone monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 1.1–2.2 | IM | Papich Saunders Handbook of Veterinary Drugs, 4th edp.512 | • 1.1-2.2 mg/kg every 7 days IM. |
| 3–5 | IM | Papich Saunders Handbook of Veterinary Drugs, 4th edp.512 | • Prostatic disease (dogs): 3-5 mg/kg IM or SQ every 3-4 weeks. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Synthetic progestin that suppresses gonadotropin secretion, inhibiting ovulation and estrus. Also used for behavioral modification and dermatologic conditions.
Increased risk of pyometra, mammary neoplasia, diabetes mellitus, and adrenocortical suppression. Use spaying as preferred alternative. Not for long-term use.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Medroxyprogesterone Acetate dose range in dogs, with cited source references: SC 2–5 mg/kg Single injection during anestrus. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Medroxyprogesterone Acetate in dogs: SC.
Cited course lengths for Medroxyprogesterone Acetate in dogs include: Single injection; provides 4-6 months estrus suppression. Duration depends on the indication — match it to the specific dose rule in the table above.
Medroxyprogesterone Acetate is indicated in dogs for: Estrus suppression.
These are general warnings for Medroxyprogesterone Acetate across species; consult the dog dosing table above for species-specific guidance. Increased risk of pyometra, mammary neoplasia, diabetes mellitus, and adrenocortical suppression. Use spaying as preferred alternative. Not for long-term use.
Why a species-specific page? Medroxyprogesterone Acetate pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.