Medroxyprogesterone Acetate for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Medroxyprogesterone Acetate is used in dog for Estrus suppression. Routes documented in dog: SC. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Medroxyprogesterone Acetate in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Depo-Provera, Provera
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| SC | 2–5 mg/kg | Single injection during anestrus | Single injection; provides 4-6 months estrus suppression | Estrus suppression | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Synthetic progestin that suppresses gonadotropin secretion, inhibiting ovulation and estrus. Also used for behavioral modification and dermatologic conditions.
Side effects & warnings
Increased risk of pyometra, mammary neoplasia, diabetes mellitus, and adrenocortical suppression. Use spaying as preferred alternative. Not for long-term use.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Reproductive drugs with dog dosing
Medroxyprogesterone Acetate dosing in other species
Why a species-specific page? Medroxyprogesterone Acetate pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.