Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Estriol is dosed at 0.5–2 mg/dog (PER ANIMAL - NOT mg/kg) PO q24h; 2 mg x14d min, then taper to 0.5 mg q24-48h in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.483, Estriol monograph spanning p.483-484; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — located 2026-08-05 in Plumb's 10th ed, Estriol monograph, printed p.483-484; the earlier note claiming no held source contained this figure was wrong and has been removed. — figure located 2026-08-05 at Plumb's 10th ed printed p.484, Estriol monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Estriol is used in dogs for Urinary incontinence (spay incontinence). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Estriol in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Incurin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–2 mg/dog (PER ANIMAL - NOT mg/kg)max 2 mg total | q24h; 2 mg x14d min, then taper to 0.5 mg q24-48h |
| Loading dose 14 days, then taper to lowest effective maintenance dose (often every 2-3 days) |
| Urinary incontinence (spay incontinence) |
| Strong |
| Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.483, Estriol monograph spanning p.483-484; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — located 2026-08-05 in Plumb's 10th ed, Estriol monograph, printed p.483-484; the earlier note claiming no held source contained this figure was wrong and has been removed. — figure located 2026-08-05 at Plumb's 10th ed printed p.484, Estriol monograph; the page cited previously does not carry it. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
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Short-acting natural estrogen that increases urethral sphincter tone and mucosal sensitivity. Minimal systemic estrogenic effects compared to other estrogens.
Lower risk of bone marrow suppression than other estrogens. Vulvar swelling and attracting males possible. Use lowest effective dose.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Estriol dose range in dogs, with cited source references: PO 0.5–2 mg/dog (PER ANIMAL - NOT mg/kg) q24h; 2 mg x14d min, then taper to 0.5 mg q24-48h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Estriol in dogs: PO.
Cited course lengths for Estriol in dogs include: Loading dose 14 days, then taper to lowest effective maintenance dose (often every 2-3 days). Duration depends on the indication — match it to the specific dose rule in the table above.
Estriol is indicated in dogs for: Urinary incontinence (spay incontinence).
These are general warnings for Estriol across species; consult the dog dosing table above for species-specific guidance. Lower risk of bone marrow suppression than other estrogens. Vulvar swelling and attracting males possible. Use lowest effective dose.
Why a species-specific page? Estriol pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.