Reptile · Eublepharis macularius · typical adult weight 0.04–0.10 kg
Midazolam is dosed at 0.5–2 mg/kg IM not stated in source in leopard geckos, per 63. Carpenter JW, Klaphake E, Gibbons PM, et al. Reptile formulary. In: Divers SJ, Stahl SJ, eds. Mader's Reptile and Amphibian Medicine and Surgery, 3rd ed., Elsevier, St. Louis, MO; 2019:1191-1211. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.246 (2026-08-01, PENDING REVIEW). Midazolam is used in leopard geckos for Sedation / preanaesthetic, Sedation for physical examination and venipuncture (combination component). Routes documented in leopard geckos: IM, SC. A typical adult leopard gecko weighs 0.04–0.10 kg. ExoticRx lists 2 cited dose rules for Midazolam in leopard geckos, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Versed
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IM | 0.5–2 mg/kg | not stated in source | Sedation / preanaesthetic | Weak | 63. Carpenter JW, Klaphake E, Gibbons PM, et al. Reptile formulary. In: Divers SJ, Stahl SJ, eds. Mader's Reptile and Amphibian Medicine and Surgery, 3rd ed., Elsevier, St. Louis, MO; 2019:1191-1211. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.246 (2026-08-01, PENDING REVIEW) |
| SC | 1 mg/kg | single dose, combined with either alfaxalone 15 | Sedation for physical examination and venipuncture (combination component) | Strong | Doss GA, Fink DM, Sladky KK, Mans C. Comparison of subcutaneous dexmedetomidine-midazolam versus alfaxalone-midazolam sedation in leopard geckos (Eublepharis macularius). Vet Anaesth Analg. 2017;44(5):1175-1183. doi:10.1016/j.vaa.2017.03.007 https://europepmc.org/abstract/MED/28882371 |
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Enhances GABA-A receptor activity, increasing chloride conductance. Provides anxiolysis, sedation, muscle relaxation, and anticonvulsant effects.
May cause paradoxical excitement in healthy dogs when used alone. Water-soluble (less painful IM than diazepam). Respiratory depression at high doses. Flumazenil is the reversal agent.
Species-specific contraindications and adverse-reaction reports for leopard geckos may differ from canine / feline reference data — consult the primary citations listed with each rule.
Midazolam dose ranges in leopard geckos, with cited source references: IM 0.5–2 mg/kg not stated in source; SC 1 mg/kg single dose, combined with either alfaxalone 15. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Midazolam in leopard geckos: IM, SC.
Midazolam is indicated in leopard geckos for: Sedation / preanaesthetic, Sedation for physical examination and venipuncture (combination component).
These are general warnings for Midazolam across species; consult the leopard gecko dosing table above for species-specific guidance. May cause paradoxical excitement in healthy dogs when used alone. Water-soluble (less painful IM than diazepam). Respiratory depression at high doses. Flumazenil is the reversal agent.
Why a species-specific page? Midazolam pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in leopard geckos — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.