Pocket Pet · Cavia porcellus · typical adult weight 0.70–1.20 kg
Naloxone is dosed at 0.01–0.1 mg/kg SC, IP not stated in source in guinea pigs, per Henke J, Baumgartner C, Roltgen I, et al. Anaesthesia with midazolam/medetomidine/fentanyl in chinchillas (Chinchilla lanigera) compared to anaesthesia with xylazine/ketamine and medetomidine/ketamine. J Vet Med A Physiol Pathol Clin Med. 2004;51:259-264. / Huerkamp M. Anesthesia and postoperative management of rabbits and pocket pets. In: Bonagura JD, eds. Kirk's Current Veterinary Therapy XII Small Animal Practice; W.B. Saunders, Philadelphia, PA; 1995:1322-1327. / Mayer J. Rodents. In: Carpenter JW, eds. Exotic Animal Formulary, 4th ed., Saunders/Elsevier, St. Louis, MO; 2013:476-516. / Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.787 (2026-08-01, PENDING REVIEW). Naloxone is used in guinea pigs for Opioid reversal. Routes documented in guinea pigs: SC, IP. A typical adult guinea pig weighs 0.70–1.20 kg. ExoticRx lists 1 cited dose rule for Naloxone in guinea pigs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Narcan
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| SC, IP | 0.01–0.1 mg/kg | not stated in source | Opioid reversal | Moderate | Henke J, Baumgartner C, Roltgen I, et al. Anaesthesia with midazolam/medetomidine/fentanyl in chinchillas (Chinchilla lanigera) compared to anaesthesia with xylazine/ketamine and medetomidine/ketamine. J Vet Med A Physiol Pathol Clin Med. 2004;51:259-264. / Huerkamp M. Anesthesia and postoperative management of rabbits and pocket pets. In: Bonagura JD, eds. Kirk's Current Veterinary Therapy XII Small Animal Practice; W.B. Saunders, Philadelphia, PA; 1995:1322-1327. / Mayer J. Rodents. In: Carpenter JW, eds. Exotic Animal Formulary, 4th ed., Saunders/Elsevier, St. Louis, MO; 2013:476-516. / Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.787 (2026-08-01, PENDING REVIEW) |
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These ranges are per kg. Enter your guinea pig's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Competitive mu, kappa, and delta opioid receptor antagonist. Rapidly reverses opioid-induced respiratory depression, sedation, and hypotension.
Very short duration (30-60 min) — renarcotization risk with long-acting opioids. May precipitate acute withdrawal, pain, and sympathetic surge. Repeat dosing often needed.
Species-specific contraindications and adverse-reaction reports for guinea pigs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Naloxone dose range in guinea pigs, with cited source references: SC, IP 0.01–0.1 mg/kg not stated in source. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Naloxone in guinea pigs: SC, IP.
Naloxone is indicated in guinea pigs for: Opioid reversal.
These are general warnings for Naloxone across species; consult the guinea pig dosing table above for species-specific guidance. Very short duration (30-60 min) — renarcotization risk with long-acting opioids. May precipitate acute withdrawal, pain, and sympathetic surge. Repeat dosing often needed.
Why a species-specific page? Naloxone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in guinea pigs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.