Question 1

What is Naloxone used for?

Accepted Answer

Naloxone is indicated for: Opioid reversal.

Question 2

What routes can Naloxone be administered by?

Accepted Answer

Available routes: IV, IM, SC, Intranasal.

Question 3

Which species have cited Naloxone dosing data?

Accepted Answer

Naloxone dosing in the ExoticRx formulary covers 5 species: African Grey Parrot, Bearded Dragon, Cat (Domestic), Dog (Domestic), Rabbit (Domestic).

Question 4

Is Naloxone a controlled substance?

Accepted Answer

Naloxone is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Naloxone?

Accepted Answer

Very short duration (30-60 min) — renarcotization risk with long-acting opioids. May precipitate acute withdrawal, pain, and sympathetic surge. Repeat dosing often needed.

Question 6

What are the side effects of Naloxone?

Accepted Answer

Reported side effects, adverse reactions, and contraindications for Naloxone: Very short duration (30-60 min) — renarcotization risk with long-acting opioids. May precipitate acute withdrawal, pain, and sympathetic surge. Repeat dosing often needed.

Question 7

How does Naloxone work?

Accepted Answer

Competitive mu, kappa, and delta opioid receptor antagonist. Rapidly reverses opioid-induced respiratory depression, sedation, and hypotension.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	0.01–0.04 mg/kg	IV bolus, repeat as needed	Strong	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	IV	0.01–0.04 mg/kg	IV bolus, repeat as needed	Strong	Plumb's Veterinary Drug Handbook, 9th Ed

Naloxone

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Naloxone dosing data (5 dose rules)

Evidence levels across 5 dose rules

Backed by 2 published sources

Sample dosing (2 of 5 cited rules)

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