ExoticRx · exoticrx.com/drugs/nepafenac-ophthalmic
US brand names:Nevanac
NSAID prodrug converted to amfenac by intraocular hydrolases. Inhibits COX-1 and COX-2 in ocular tissues, reducing prostaglandin-mediated inflammation and pain.
Shake well before use. May delay corneal healing. Avoid with corneal ulcers. Used perioperatively and for uveitis. Less corneal toxicity than some older NSAIDs.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | TOPICAL (ophthalmic) | NSAID prodrug with good intraocular penetration | q8-12h | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1415 (2026-08-01). |
| Cat (Domestic) | TOPICAL (ophthalmic) | Limited feline data | q8-12h | Extrapolated | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1415 (2026-08-01). |
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