ExoticRx · exoticrx.com/drugs/nizatidine
US brand names:Axid
Nizatidine is dosed at 2.5–5 mg/kg PO q24h in cats, per Hall JA, Washabau RJ. Diagnosis and treatment of gastric motility disorders. Vet Clin North Am Small Animal Pract. 1999;29(2):377-395. doi:10.1016/s0195-5616(99)50027-2; Whitehead K, Cortes Y, Eirmann L. Gastrointestinal dysmotility disorders in critically ill dogs and cats. J Vet Emerg Crit Care. 2016;26(2):234-253. doi:10.1111/vec.12449 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.969 (2026-08-01). — Plumb's 10th ed (held) printed p.942, Nizatidine monograph spanning p.941-942; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Verify against current literature before clinical use.
Competitive H2 receptor antagonist that reduces gastric acid secretion. Uniquely among H2 blockers, also inhibits acetylcholinesterase, providing prokinetic activity.
Dual benefit of acid reduction and prokinetic effect. Fewer drug interactions than cimetidine. Monitor hepatic/renal function.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | PO | 2.5–5 mg/kg | q24h | Weak | Hall JA, Washabau RJ. Diagnosis and treatment of gastric motility disorders. Vet Clin North Am Small Animal Pract. 1999;29(2):377-395. doi:10.1016/s0195-5616(99)50027-2; Whitehead K, Cortes Y, Eirmann L. Gastrointestinal dysmotility disorders in critically ill dogs and cats. J Vet Emerg Crit Care. 2016;26(2):234-253. doi:10.1111/vec.12449 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.969 (2026-08-01). — Plumb's 10th ed (held) printed p.942, Nizatidine monograph spanning p.941-942; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Dog (Domestic) | PO | 2.5–5 mg/kg | q24h |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
| Extrapolated |
| Plumb's Veterinary Drug Handbook, 10th ed. (2023), printed p.942 (corpus PDF p.969), DOGS/CATS (extra-label). Corroborated by Papich, Saunders Handbook of Veterinary Drugs 4th ed. (2016), printed p.572: 'Dogs - 2.5-5 mg/kg q24h PO.' — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |