ExoticRx · exoticrx.com/drugs/olsalazine
US brand names:Dipentum
Olsalazine is dosed at 5–15 mg/kg PO q8-12h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.979 (2026-08-01).. Verify against current literature before clinical use.
Dimer of mesalamine cleaved by colonic bacteria to release two molecules of 5-aminosalicylic acid locally, exerting anti-inflammatory effects on colonic mucosa.
Diarrhea may worsen initially (secretory). Avoid in salicylate hypersensitivity. Monitor renal function with long-term use.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 5–15 mg/kg | q8-12h | Weak | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.979 (2026-08-01). |
| Cat (Domestic) | PO | 5–10 mg/kg | q12h | Extrapolated | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.