ExoticRx · exoticrx.com/drugs/olsalazine
US brand names:Dipentum
Olsalazine is dosed at 5–15 mg/kg PO q8h in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.979 (2026-08-01). — Plumb's 10th ed (held) printed p.952, Olsalazine monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Verify against current literature before clinical use.
Dimer of mesalamine cleaved by colonic bacteria to release two molecules of 5-aminosalicylic acid locally, exerting anti-inflammatory effects on colonic mucosa.
Diarrhea may worsen initially (secretory). Avoid in salicylate hypersensitivity. Monitor renal function with long-term use.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 5–15 mg/kg | q8h | Weak | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.979 (2026-08-01). — Plumb's 10th ed (held) printed p.952, Olsalazine monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Cat (Domestic) | PO | 5–10 mg/kg | q12h | Extrapolated | Papich, Saunders Handbook of Veterinary Drugs, 5th ed, printed pp.576-577 (corpus pdf pp.604-605), Olsalazine Sodium, Small Animal Dosage: 'Dose not established, but 5-10 mg/kg q8h have been used.' — EDITION UNVERIFIABLE 2026-08-07: this citation names Papich 5th ed, which is NOT held. Its page locator does not resolve to a page naming this drug in the held 4th ed (2016), so the reference cannot be confirmed against any copy available here. Treat the page number as unchecked and consult the 5th edition directly. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, |
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