Cat · Felis catus · typical adult weight 2.50–7.00 kg
Ondansetron is dosed at 0.1–0.2 mg/kg IV q6-12h in cats, per Wittenburg L. Impact of disease states and organ function on pharmacokinetics. Presented at: Pacific Veterinary Conference; 2016. PMID: 40577388 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.984 (2026-08-01). — Plumb's 10th ed (held) printed p.957, Ondansetron monograph spanning p.956-957; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Ondansetron is used in cats for Severe vomiting. Routes documented in cats: IV. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Ondansetron in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zofran
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.1–0.2 mg/kg | q6-12h | As needed | Severe vomiting | Moderate | Wittenburg L. Impact of disease states and organ function on pharmacokinetics. Presented at: Pacific Veterinary Conference; 2016. PMID: 40577388 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.984 (2026-08-01). — Plumb's 10th ed (held) printed p.957, Ondansetron monograph spanning p.956-957; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.309 | 0.5 mg/kg i.v. loading dose followed by 0.5 mg/kg/h infusion for 6 hours or 0.5-1 mg/kg p.o. q12-24 |
| 0.5–1 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.309 | oading dose followed by 0.5 mg/kg/h infusion for 6 hours or 0.5-1 mg/kg p.o. q12-24h. |
| 0.5 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.609 | • Similar doses as dogs have been administered, or 0.5 mg/kg q12h SQ, IV, or PO. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Selectively blocks serotonin 5-HT3 receptors in the chemoreceptor trigger zone and vagal afferents, preventing nausea and vomiting.
Very effective antiemetic. May cause constipation, headache. IV push over 2-5 minutes. QT prolongation reported at high doses. Off-label in veterinary medicine.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ondansetron dose range in cats, with cited source references: IV 0.1–0.2 mg/kg q6-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ondansetron in cats: IV.
Cited course lengths for Ondansetron in cats include: As needed. Duration depends on the indication — match it to the specific dose rule in the table above.
Ondansetron is indicated in cats for: Severe vomiting.
These are general warnings for Ondansetron across species; consult the cat dosing table above for species-specific guidance. Very effective antiemetic. May cause constipation, headache. IV push over 2-5 minutes. QT prolongation reported at high doses. Off-label in veterinary medicine.
Why a species-specific page? Ondansetron pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.