Cat · Felis catus · typical adult weight 2.50–7.00 kg
Ondansetron is dosed at 0.1–0.2 mg/kg IV q6-12h in cats, per Wittenburg L. Impact of disease states and organ function on pharmacokinetics. Presented at: Pacific Veterinary Conference; 2016. PMID: 40577388 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.984 (2026-08-01).. Ondansetron is used in cats for Severe vomiting. Routes documented in cats: IV. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Ondansetron in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zofran
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.1–0.2 mg/kg | q6-12h | As needed | Severe vomiting | Moderate | Wittenburg L. Impact of disease states and organ function on pharmacokinetics. Presented at: Pacific Veterinary Conference; 2016. PMID: 40577388 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.984 (2026-08-01). |
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Selectively blocks serotonin 5-HT3 receptors in the chemoreceptor trigger zone and vagal afferents, preventing nausea and vomiting.
Very effective antiemetic. May cause constipation, headache. IV push over 2-5 minutes. QT prolongation reported at high doses. Off-label in veterinary medicine.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ondansetron dose range in cats, with cited source references: IV 0.1–0.2 mg/kg q6-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ondansetron in cats: IV.
Cited course lengths for Ondansetron in cats include: As needed. Duration depends on the indication — match it to the specific dose rule in the table above.
Ondansetron is indicated in cats for: Severe vomiting.
These are general warnings for Ondansetron across species; consult the cat dosing table above for species-specific guidance. Very effective antiemetic. May cause constipation, headache. IV push over 2-5 minutes. QT prolongation reported at high doses. Off-label in veterinary medicine.
Why a species-specific page? Ondansetron pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.