Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Ondansetron is dosed at 0.1–0.2 mg/kg IV q6-12h in dogs, per Papich, Saunders Handbook of Veterinary Drugs, 5th ed, printed p.581 (corpus pdf p.609), Ondansetron Hydrochloride, Dogs: 'Vomiting from other causes: 0.1-0.2 mg/kg slow IV injection and repeated q6-12h.'. Ondansetron is used in dogs for Severe vomiting, chemotherapy-induced nausea, Nausea and vomiting. Routes documented in dogs: IV, PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Ondansetron in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zofran
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.1–0.2 mg/kg | q6-12h | As needed | Severe vomiting, chemotherapy-induced nausea | Moderate | Papich, Saunders Handbook of Veterinary Drugs, 5th ed, printed p.581 (corpus pdf p.609), Ondansetron Hydrochloride, Dogs: 'Vomiting from other causes: 0.1-0.2 mg/kg slow IV injection and repeated q6-12h.' |
| PO | 0.5–1 mg/kg | q12-24h | As needed | Nausea and vomiting | Moderate | Plumb's Veterinary Drug Handbook, 10th Ed (2023), p.984 — Ondansetron, Dosages, DOGS, Antiemetic (extra-label). Corroborated: Papich, Saunders Handbook of Veterinary Drugs, 4th Ed (2016), p.609, Dogs: '0.5-1 mg/kg... These doses can also be administered PO, but oral absorption is low in dogs (<10%)'. |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Selectively blocks serotonin 5-HT3 receptors in the chemoreceptor trigger zone and vagal afferents, preventing nausea and vomiting.
Very effective antiemetic. May cause constipation, headache. IV push over 2-5 minutes. QT prolongation reported at high doses. Off-label in veterinary medicine.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ondansetron dose ranges in dogs, with cited source references: IV 0.1–0.2 mg/kg q6-12h; PO 0.5–1 mg/kg q12-24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ondansetron in dogs: IV, PO.
Cited course lengths for Ondansetron in dogs include: As needed. Duration depends on the indication — match it to the specific dose rule in the table above.
Ondansetron is indicated in dogs for: Severe vomiting, chemotherapy-induced nausea, Nausea and vomiting.
These are general warnings for Ondansetron across species; consult the dog dosing table above for species-specific guidance. Very effective antiemetic. May cause constipation, headache. IV push over 2-5 minutes. QT prolongation reported at high doses. Off-label in veterinary medicine.
Why a species-specific page? Ondansetron pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.