Ondansetron for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Ondansetron is used in dog for Severe vomiting, chemotherapy-induced nausea, Nausea and vomiting. Routes documented in dog: IV, PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Ondansetron in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Zofran
Dose ranges
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Selectively blocks serotonin 5-HT3 receptors in the chemoreceptor trigger zone and vagal afferents, preventing nausea and vomiting.
Side effects & warnings
Very effective antiemetic. May cause constipation, headache. IV push over 2-5 minutes. QT prolongation reported at high doses. Off-label in veterinary medicine.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Gastrointestinal drugs with dog dosing
Ondansetron dosing in other species
Why a species-specific page? Ondansetron pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.