ExoticRx · exoticrx.com/drugs/ondansetron
US brand names:Zofran
Ondansetron is dosed at 0.1–0.2 mg/kg SC q8-12h in ferrets, per Carpenter 6e. Verify against current literature before clinical use.
Selectively blocks serotonin 5-HT3 receptors in the chemoreceptor trigger zone and vagal afferents, preventing nausea and vomiting.
Very effective antiemetic. May cause constipation, headache. IV push over 2-5 minutes. QT prolongation reported at high doses. Off-label in veterinary medicine.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Ferret drugs
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A dog/cat sample is shown here. Cited dosing for all 3 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.5–1 mg/kg | q12-24h | Moderate | Papich Handbook of Veterinary Drugs, 5th Ed |
| Cat (Domestic) | IV | 0.1–0.2 mg/kg | q6-12h | Moderate | Wittenburg L. Impact of disease states and organ function on pharmacokinetics. Presented at: Pacific Veterinary Conference; 2016. PMID: 40577388 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.984 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.