ExoticRx · exoticrx.com/drugs/ondansetron
US brand names:Zofran
Ondansetron is dosed at 0.5 mg/kg IM, IV, PO q8h (IM, IV or PO) in ferrets, per Carpenter 6e — Carpenter's Exotic Animal Formulary, 6th ed, Table 11.10 (corpus PDF pp.954-957); located 2026-08-06 by chapter-governed table: this table is in the chapter covering this species and names this drug. NOTE: the served figure was matched against the table as a whole, not against this drug's own row, so confirm the number on the page before relying on it. The held copy has no printed page numbers, so the numbered table is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.
Selectively blocks serotonin 5-HT3 receptors in the chemoreceptor trigger zone and vagal afferents, preventing nausea and vomiting.
Very effective antiemetic. May cause constipation, headache. IV push over 2-5 minutes. QT prolongation reported at high doses. Off-label in veterinary medicine.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Ferret drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 3 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | IV | 0.1–0.2 mg/kg | q6-12h | Moderate | Wittenburg L. Impact of disease states and organ function on pharmacokinetics. Presented at: Pacific Veterinary Conference; 2016. PMID: 40577388 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.984 (2026-08-01). — Plumb's 10th ed (held) printed p.957, Ondansetron monograph spanning p.956-957; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Dog (Domestic) | PO | 0.5–1 mg/kg | q12-24h | Weak |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.