Question 1

What is Ondansetron used for?

Accepted Answer

Ondansetron is indicated for: chemotherapy, chemotherapy-induced nausea, Nausea and vomiting, Refractory vomiting, Severe vomiting.

Question 2

What routes can Ondansetron be administered by?

Accepted Answer

Available routes: PO, IV.

Question 3

Which species have cited Ondansetron dosing data?

Accepted Answer

Ondansetron dosing in the ExoticRx formulary covers 3 species: Cat (Domestic), Dog (Domestic), Ferret.

Question 4

Is Ondansetron a controlled substance?

Accepted Answer

Ondansetron is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Ondansetron?

Accepted Answer

Very effective antiemetic. May cause constipation, headache. IV push over 2-5 minutes. QT prolongation reported at high doses. Off-label in veterinary medicine.

Question 6

What are the side effects of Ondansetron?

Accepted Answer

Reported side effects, adverse reactions, and contraindications for Ondansetron: Very effective antiemetic. May cause constipation, headache. IV push over 2-5 minutes. QT prolongation reported at high doses. Off-label in veterinary medicine.

Question 7

How does Ondansetron work?

Accepted Answer

Selectively blocks serotonin 5-HT3 receptors in the chemoreceptor trigger zone and vagal afferents, preventing nausea and vomiting.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	IV	0.1–0.2 mg/kg	q6-12h	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed
Dog (Domestic)	PO	0.5–1 mg/kg	q12-24h	Moderate	Papich Handbook of Veterinary Drugs, 5th Ed

Ondansetron

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Ondansetron dosing data (4 dose rules)

Evidence levels across 4 dose rules

Backed by 3 published sources

Sample dosing (2 of 4 cited rules)

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Other formulations of Ondansetron