ExoticRx · exoticrx.com/drugs/ondansetron-injectable
US brand names:Zofran Injectable
Ondansetron Injectable is dosed at 0.1–0.5 mg/kg IV q8-12h IV in dogs, per Topal A, Kaya M, Gul N. Ondansetron and granisetron in the prophylaxis of nausea and emesis induced by cisplatin in dogs. Acta Vet Brno. 2005;74(1):111-116. / 1. Yalcin E, Keser GO. Comparative efficacy of metoclopramide, ondansetron and maropitant in preventing parvoviral enteritis-induced emesis in dogs. J Vet Pharmacol Ther. 2017;40(6):599-603. doi:10.2754/avb200574010111 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.984 (2026-08-01).. Verify against current literature before clinical use.
5-HT3 serotonin receptor antagonist. Injectable form for acute nausea/vomiting in hospitalized patients unable to take oral medication.
IV route for acute vomiting/nausea. Often combined with maropitant for refractory vomiting. Constipation possible. QT prolongation at high doses.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.1–0.5 mg/kg | q8-12h IV | Strong | Topal A, Kaya M, Gul N. Ondansetron and granisetron in the prophylaxis of nausea and emesis induced by cisplatin in dogs. Acta Vet Brno. 2005;74(1):111-116. / 1. Yalcin E, Keser GO. Comparative efficacy of metoclopramide, ondansetron and maropitant in preventing parvoviral enteritis-induced emesis in dogs. J Vet Pharmacol Ther. 2017;40(6):599-603. doi:10.2754/avb200574010111 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.984 (2026-08-01). |
| Cat (Domestic) | IV | 0.1–0.5 mg/kg | q8-12h IV | Moderate | Quimby JM, Lake RC, Hansen RJ, Lunghofer PJ, Gustafson DL. Oral, subcutaneous, and intravenous pharmacokinetics of ondansetron in healthy cats. J Vet Pharmacol Ther. 2014;37(4):348-353. doi:10.1111/jvp.12094 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.984 (2026-08-01). |
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