Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Ondansetron Injectable is dosed at 0.1–0.5 mg/kg IV q8-12h IV in dogs, per Topal A, Kaya M, Gul N. Ondansetron and granisetron in the prophylaxis of nausea and emesis induced by cisplatin in dogs. Acta Vet Brno. 2005;74(1):111-116. / 1. Yalcin E, Keser GO. Comparative efficacy of metoclopramide, ondansetron and maropitant in preventing parvoviral enteritis-induced emesis in dogs. J Vet Pharmacol Ther. 2017;40(6):599-603. doi:10.2754/avb200574010111 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.984 (2026-08-01). — Plumb's 10th ed (held) printed p.956, Ondansetron monograph spanning p.956-957; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Ondansetron Injectable is used in dogs for Acute vomiting (hospitalized). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Ondansetron Injectable in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zofran Injectable
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.1–0.5 mg/kg | q8-12h IV | As needed | Acute vomiting (hospitalized) | Strong | Topal A, Kaya M, Gul N. Ondansetron and granisetron in the prophylaxis of nausea and emesis induced by cisplatin in dogs. Acta Vet Brno. 2005;74(1):111-116. / 1. Yalcin E, Keser GO. Comparative efficacy of metoclopramide, ondansetron and maropitant in preventing parvoviral enteritis-induced emesis in dogs. J Vet Pharmacol Ther. 2017;40(6):599-603. doi:10.2754/avb200574010111 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.984 (2026-08-01). — Plumb's 10th ed (held) printed p.956, Ondansetron monograph spanning p.956-957; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (%) | Route | Source | As printed |
|---|---|---|---|
| 10 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.609 | (,10%), which may compromise the effectiveness. |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.309 | 0.5 mg/kg i.v. loading dose followed by 0.5 mg/kg/h infusion for 6 hours or 0.5-1 mg/kg p.o. q12-24 |
| 0.5–1 |
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5-HT3 serotonin receptor antagonist. Injectable form for acute nausea/vomiting in hospitalized patients unable to take oral medication.
IV route for acute vomiting/nausea. Often combined with maropitant for refractory vomiting. Constipation possible. QT prolongation at high doses.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ondansetron Injectable dose range in dogs, with cited source references: IV 0.1–0.5 mg/kg q8-12h IV. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ondansetron Injectable in dogs: IV.
Cited course lengths for Ondansetron Injectable in dogs include: As needed. Duration depends on the indication — match it to the specific dose rule in the table above.
Ondansetron Injectable is indicated in dogs for: Acute vomiting (hospitalized).
These are general warnings for Ondansetron Injectable across species; consult the dog dosing table above for species-specific guidance. IV route for acute vomiting/nausea. Often combined with maropitant for refractory vomiting. Constipation possible. QT prolongation at high doses.
Why a species-specific page? Ondansetron Injectable pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| PO |
| BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.309 |
| oading dose followed by 0.5 mg/kg/h infusion for 6 hours or 0.5-1 mg/kg p.o. q12-24h. |
| 0.5–1 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.609 | • 0.5-1 mg/kg 30 min prior to administration of cancer drugs intravenously. |
| 0.1–0.2 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.609 | Vomiting from other causes: 0.1-0.2 mg/kg slow IV injection and repeated |
| 0.5 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.609 | q6-12h. If this dose is initially ineffective, it may be increased to 0.5 mg/kg. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.