ExoticRx · exoticrx.com/drugs/phenylephrine
US brand names:Neo-Synephrine
Phenylephrine is dosed at 0.5–5 mcg/kg/min IV CRI in dogs, per Ko J. Anesthesia monitoring techniques and management. Presented at: Proceedings: ACVC; 2009. PMID: 42484292 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1043 (2026-08-01).. Verify against current literature before clinical use.
Selective alpha-1 adrenergic agonist causing vasoconstriction without direct cardiac stimulation. Increases SVR and blood pressure. Reflex bradycardia.
Pure vasopressor — no inotropic effect. Reflex bradycardia expected. Tissue necrosis with extravasation. Also used ophthalmically for mydriasis (2.5% — avoid 10% in small animals).
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Phenylephrine CRI dose rule from the ExoticRx formulary. Verify against current literature before clinical use; CRI rates differ from bolus dosing and route, dilution, and monitoring matter. Sign in for the complete per-species CRI protocol set.
| Species | Route | Rate | Indication | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.5–5 mcg/kg/minCRI | Refractory hypotension (vasopressor) | Moderate | Ko J. Anesthesia monitoring techniques and management. Presented at: Proceedings: ACVC; 2009. PMID: 42484292 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1043 (2026-08-01). |
Refractory hypotension (vasopressor)
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.5–5 mcg/kg/min | CRI | Moderate | Ko J. Anesthesia monitoring techniques and management. Presented at: Proceedings: ACVC; 2009. PMID: 42484292 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1043 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.