ExoticRx · exoticrx.com/drugs/phenylephrine-injectable
US brand names:Neo-Synephrine Injectable
Phenylephrine Injectable is dosed at 0.001–0.003 mg/kg/min CRI IV CRI titrated to effect in dogs, per Ko J. Anesthesia monitoring techniques and management. Presented at: Proceedings: ACVC; 2009. PMID: 42484292 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1043 (2026-08-01).. Verify against current literature before clinical use.
Selective alpha-1 adrenergic agonist causing peripheral vasoconstriction, increasing systemic vascular resistance and blood pressure without significant cardiac stimulation.
Reflex bradycardia common. Extravasation causes tissue necrosis — use central line when possible. Contraindicated in severe hypertension. Titrate to effect.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Phenylephrine Injectable CRI dose rules from the ExoticRx formulary. Verify against current literature before clinical use; CRI rates differ from bolus dosing and route, dilution, and monitoring matter. Sign in for the complete per-species CRI protocol set.
| Species | Route | Rate | Indication | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.001–0.003 mg/kg/min CRICRI titrated to effect | Vasodilatory shock/Severe hypotension | Moderate | Ko J. Anesthesia monitoring techniques and management. Presented at: Proceedings: ACVC; 2009. PMID: 42484292 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1043 (2026-08-01). |
| Cat (Domestic) | IV | 0.001–0.003 mg/kg bolus or CRIBolus q5min or CRI to effect | Severe hypotension under anesthesia | Moderate | Veterinary Anesthesia Textbooks; Plumb's 9th Ed |
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.001–0.003 mg/kg/min CRI | CRI titrated to effect | Moderate | Ko J. Anesthesia monitoring techniques and management. Presented at: Proceedings: ACVC; 2009. PMID: 42484292 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1043 (2026-08-01). |
| Cat (Domestic) | IV | 0.001–0.003 mg/kg bolus or CRI | Bolus q5min or CRI to effect | Moderate | Veterinary Anesthesia Textbooks; Plumb's 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
Vasodilatory shock/Severe hypotension
Severe hypotension under anesthesia