Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Contraindicated in Rabbit, Guinea Pig, Chinchilla, Hamster, Degu
Piperacillin-Tazobactam is dosed at 40–50 mg/kg IV q6h (each dose IV over 30 min) in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023), Piperacillin/Tazobactam monograph, DOGS, printed p.1030: "Bacterial sepsis (extra-label): 40 - 50 mg/kg IV over 30 minutes every 6 hours have been suggested." Harada et al. 2025, Antibiotics 14(5):425, "a dose of 50 mg/kg has been widely authorized in dogs"; the maximum nontoxic dose in dogs is 200 mg/kg/day, "which corresponds to 50 mg/kg q6h". — Plumb's Veterinary Drug Handbook, 10th ed (2023) — Plumb's 10th ed printed p.1029, Piperacillin/Tazobactam monograph spanning p.1029-1030. — Plumb's 10th ed printed p.1030, Piperacillin/Tazobactam monograph. Piperacillin-Tazobactam is used in dogs for Severe mixed/resistant infections, sepsis. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Piperacillin-Tazobactam in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zosyn
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 40–50 mg/kg | q6h (each dose IV over 30 min) | 7-14 days | Severe mixed/resistant infections, sepsis | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023), Piperacillin/Tazobactam monograph, DOGS, printed p.1030: "Bacterial sepsis (extra-label): 40 - 50 mg/kg IV over 30 minutes every 6 hours have been suggested." Harada et al. 2025, Antibiotics 14(5):425, doi:10.3390/antibiotics14050425: "a dose of 50 mg/kg has been widely authorized in dogs"; the maximum nontoxic dose in dogs is 200 mg/kg/day, "which corresponds to 50 mg/kg q6h". — Plumb's Veterinary Drug Handbook, 10th ed (2023) — Plumb's 10th ed printed p.1029, Piperacillin/Tazobactam monograph spanning p.1029-1030. — Plumb's 10th ed printed p.1030, Piperacillin/Tazobactam monograph. |
Typical range: 2–80 kg
If provided, volume will be calculated alongside dose.
Reference only. Verify against current literature before clinical use.
Piperacillin inhibits cell wall synthesis; tazobactam inhibits many beta-lactamases restoring activity against resistant organisms.
Adjust dose for renal impairment. Monitor bleeding (platelet dysfunction). GI upset. Sodium content may be significant in fluid-restricted patients.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Piperacillin-Tazobactam dose range in dogs, with cited source references: IV 40–50 mg/kg q6h (each dose IV over 30 min). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Piperacillin-Tazobactam in dogs: IV.
Cited course lengths for Piperacillin-Tazobactam in dogs include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Piperacillin-Tazobactam is indicated in dogs for: Severe mixed/resistant infections, sepsis.
These are general warnings for Piperacillin-Tazobactam across species; consult the dog dosing table above for species-specific guidance. Adjust dose for renal impairment. Monitor bleeding (platelet dysfunction). GI upset. Sodium content may be significant in fluid-restricted patients.
Why a species-specific page? Piperacillin-Tazobactam pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.