ExoticRx · exoticrx.com/drugs/polymyxin-b
US brand names:Poly-Rx
Polymyxin B is dosed at 50000 U/L drinking water PO (drinking water) Continuous in drinking water in canaries, per Johnson-Delaney CA, Harrison LR, eds. Exotic Companion Medicine Handbook for Veterinarians, Wingers Publishing, Lake Worth, FL; 1996. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.420 — Carpenter's Exotic Animal Formulary 6th ed, Table 5.1 (Antimicrobial Agents Used in Birds.a). Verify against current literature before clinical use.
Binds to lipopolysaccharide in gram-negative bacterial outer membrane causing cell lysis. Bactericidal and concentration-dependent.
Highly nephrotoxic and neurotoxic systemically. Topical use is safer. Reserve systemic use for MDR gram-negative infections.
Species references:All Canary drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1–2.5 mg/kg | q12h | Weak | Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.649Compilation only — we have not located an independent source that prints this figure. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.