Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Polymyxin B is dosed at 1–2.5 mg/kg IV q12h in dogs, per Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.677 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.677' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.649; verified by finding the drug named there. If you are holding the book, turn to p.649. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855. Polymyxin B is used in dogs for MDR gram-negative infections. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Polymyxin B in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Poly-Rx
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 1–2.5 mg/kg | q12h | 7-14 days | MDR gram-negative infections | Weak |
| Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.677 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.677' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.649; verified by finding the drug named there. If you are holding the book, turn to p.649. — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (%) | Route | Source | As printed |
|---|---|---|---|
| 5 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.677 | 500,000 polymyxin B units with 300-500 mL 5% dextrose for CRI. |
| 1 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.677 | 1% procaine hydrochloride. |
| 0.9 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.677 | • Antiendotoxin: 1 mg/kg diluted in 10 mL of 0.9% saline solution given as an |
| Dose (iu/kg) | Route | Source | As printed |
|---|---|---|---|
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Binds to lipopolysaccharide in gram-negative bacterial outer membrane causing cell lysis. Bactericidal and concentration-dependent.
Highly nephrotoxic and neurotoxic systemically. Topical use is safer. Reserve systemic use for MDR gram-negative infections.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Polymyxin B dose range in dogs, with cited source references: IV 1–2.5 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Polymyxin B in dogs: IV.
Cited course lengths for Polymyxin B in dogs include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Polymyxin B is indicated in dogs for: MDR gram-negative infections.
These are general warnings for Polymyxin B across species; consult the dog dosing table above for species-specific guidance. Highly nephrotoxic and neurotoxic systemically. Topical use is safer. Reserve systemic use for MDR gram-negative infections.
Why a species-specific page? Polymyxin B pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 15000–25000 |
| IV |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.677 |
| • Antibacterial: 15,000-25,000 units/kg q12h IV. To prepare solution, mix |
| 30000 | IM | Papich Saunders Handbook of Veterinary Drugs, 4th edp.677 | • Antibacterial: 30,000 units/kg/day IM. To prepare solution, mix 500,000 poly- |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 1 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.677 | • Antiendotoxin: 1 mg/kg diluted in 10 mL of 0.9% saline solution given as an |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.