Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Polymyxin B is dosed at 1–2.5 mg/kg IV q12h in dogs, per Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.677 (2026-08-01).. Polymyxin B is used in dogs for MDR gram-negative infections. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Polymyxin B in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Poly-Rx
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 1–2.5 mg/kg | q12h | 7-14 days | MDR gram-negative infections | Weak | Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.677 (2026-08-01). |
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Binds to lipopolysaccharide in gram-negative bacterial outer membrane causing cell lysis. Bactericidal and concentration-dependent.
Highly nephrotoxic and neurotoxic systemically. Topical use is safer. Reserve systemic use for MDR gram-negative infections.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Polymyxin B dose range in dogs, with cited source references: IV 1–2.5 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Polymyxin B in dogs: IV.
Cited course lengths for Polymyxin B in dogs include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Polymyxin B is indicated in dogs for: MDR gram-negative infections.
These are general warnings for Polymyxin B across species; consult the dog dosing table above for species-specific guidance. Highly nephrotoxic and neurotoxic systemically. Topical use is safer. Reserve systemic use for MDR gram-negative infections.
Why a species-specific page? Polymyxin B pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.