ExoticRx · exoticrx.com/drugs/posaconazole
US brand names:Noxafil
Posaconazole is dosed at 5–7.5 mg/kg PO q24h (or divided into 2 doses/day) in cats, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), Posaconazole, Dosages, corpus p.1071 (printed p.1044), CATS row b — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Verify against current literature before clinical use.
Inhibits lanosterol 14-alpha demethylase (CYP51). Broadest spectrum triazole with activity against Aspergillus, Candida, Zygomycetes, and others.
Oral suspension requires fatty food for absorption. Tablet form has better bioavailability. QT prolongation risk. Hepatotoxicity monitoring recommended. Limited veterinary data.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | PO | 5–7.5 mg/kg | q24h (or divided into 2 doses/day) | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), Posaconazole, Dosages, corpus p.1071 (printed p.1044), CATS row b — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Dog (Domestic) | PO | 5–10 mg/kg | q12-24h | Weak | Corrigan VK, Legendre AM, Wheat LJ, et al. Treatment of Disseminated Aspergillosis with Posaconazole in 10 Dogs. Journal of Veterinary Internal Medicine. 2016;30:167-173. doi:10.1111/jvim.13795 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1071 (2026-08-01). — Plumb's 10th ed (held) printed p.1044, Posaconazole monograph spanning p.1043-1044; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
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