ExoticRx · exoticrx.com/drugs/pralidoxime
US brand names:2-PAM, Protopam
Pralidoxime is dosed at 10–100 mg/kg IM q24-48h or repeat once q6h in african grey parrots, per 509. LaBonde J. Toxicity in pet avian patients. Semin Avian Exot Pet Med. 1995;4:23-31. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.470 — Carpenter's Exotic Animal Formulary 6th ed, Table 5.9 (Agents Used in the Treatment of Toxicologic Conditions of Birds). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.
Reactivates acetylcholinesterase by cleaving organophosphate from enzyme active site. Must be given before aging occurs (irreversible binding).
Give within 24-48 hours of organophosphate exposure (before aging). Always co-administer atropine. Not effective for carbamate poisoning (unnecessary). Slow IV push.
Species references:All African Grey Parrot drugsAll Dog (Domestic) drugsAll Lovebird drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 3 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 20–50 mg/kg | IV slowly, repeat q8-12h | Weak | Papich MG. Saunders Handbook of Veterinary Drugs (Small and Large Animal), Pralidoxime Chloride, Small Animal Dosage, printed p.663 (corpus p.691) — SOURCE EDITION: Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |
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