ExoticRx · exoticrx.com/drugs/pralidoxime
US brand names:2-PAM, Protopam
Pralidoxime is dosed at 20–50 mg/kg IV IV slowly, repeat q8-12h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Reactivates acetylcholinesterase by cleaving organophosphate from enzyme active site. Must be given before aging occurs (irreversible binding).
Give within 24-48 hours of organophosphate exposure (before aging). Always co-administer atropine. Not effective for carbamate poisoning (unnecessary). Slow IV push.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 20–50 mg/kg | IV slowly, repeat q8-12h | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.