Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Pralidoxime is dosed at 20–50 mg/kg IV IV slowly, repeat q8-12h in dogs, per Papich MG. Saunders Handbook of Veterinary Drugs (Small and Large Animal), Pralidoxime Chloride, Small Animal Dosage, printed p.663 (corpus p.691). Pralidoxime is used in dogs for Organophosphate toxicity. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Pralidoxime in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: 2-PAM, Protopam
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 20–50 mg/kg | IV slowly, repeat q8-12h | 24-48 hours | Organophosphate toxicity | Strong | Papich MG. Saunders Handbook of Veterinary Drugs (Small and Large Animal), Pralidoxime Chloride, Small Animal Dosage, printed p.663 (corpus p.691) |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Reactivates acetylcholinesterase by cleaving organophosphate from enzyme active site. Must be given before aging occurs (irreversible binding).
Give within 24-48 hours of organophosphate exposure (before aging). Always co-administer atropine. Not effective for carbamate poisoning (unnecessary). Slow IV push.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Pralidoxime dose range in dogs, with cited source references: IV 20–50 mg/kg IV slowly, repeat q8-12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Pralidoxime in dogs: IV.
Cited course lengths for Pralidoxime in dogs include: 24-48 hours. Duration depends on the indication — match it to the specific dose rule in the table above.
Pralidoxime is indicated in dogs for: Organophosphate toxicity.
These are general warnings for Pralidoxime across species; consult the dog dosing table above for species-specific guidance. Give within 24-48 hours of organophosphate exposure (before aging). Always co-administer atropine. Not effective for carbamate poisoning (unnecessary). Slow IV push.
Why a species-specific page? Pralidoxime pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.