Pralidoxime for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Pralidoxime is used in dog for Organophosphate toxicity. Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Pralidoxime in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: 2-PAM, Protopam
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 20–50 mg/kg | IV slowly, repeat q8-12h | 24-48 hours | Organophosphate toxicity | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Reactivates acetylcholinesterase by cleaving organophosphate from enzyme active site. Must be given before aging occurs (irreversible binding).
Side effects & warnings
Give within 24-48 hours of organophosphate exposure (before aging). Always co-administer atropine. Not effective for carbamate poisoning (unnecessary). Slow IV push.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Antidote drugs with dog dosing
Why a species-specific page? Pralidoxime pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.