ExoticRx · exoticrx.com/drugs/protamine
US brand names:Protamine Sulfate
Protamine is dosed at 1 mg/dose IV IV slowly in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Strongly basic protein that forms stable complex with heparin (strongly acidic), neutralizing anticoagulant activity.
1mg protamine neutralizes ~100 units heparin. Slow IV administration. Hypotension, bradycardia, anaphylaxis risk (especially in patients with fish allergy or prior protamine exposure).
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1 mg/dose | IV slowly | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.