Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Protamine is dosed at 1 mg/dose IV IV slowly in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.674, Insulin, Protamine Zinc monograph spanning p.674-676; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Protamine is used in dogs for Heparin reversal. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Protamine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Protamine Sulfate
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 1 mg/dose | IV slowly | Single dose | Heparin reversal | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.674, Insulin, Protamine Zinc monograph spanning p.674-676; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
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Strongly basic protein that forms stable complex with heparin (strongly acidic), neutralizing anticoagulant activity.
1mg protamine neutralizes ~100 units heparin. Slow IV administration. Hypotension, bradycardia, anaphylaxis risk (especially in patients with fish allergy or prior protamine exposure).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Protamine dose range in dogs, with cited source references: IV 1 mg/dose IV slowly. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Protamine in dogs: IV.
Cited course lengths for Protamine in dogs include: Single dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Protamine is indicated in dogs for: Heparin reversal.
These are general warnings for Protamine across species; consult the dog dosing table above for species-specific guidance. 1mg protamine neutralizes ~100 units heparin. Slow IV administration. Hypotension, bradycardia, anaphylaxis risk (especially in patients with fish allergy or prior protamine exposure).
Why a species-specific page? Protamine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.