What is Rivaroxaban used for?

Rivaroxaban is indicated for: Arterial thromboembolism prevention, Thromboembolism prevention.

Which species have cited Rivaroxaban dosing data?

Rivaroxaban dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Is Rivaroxaban a controlled substance?

Rivaroxaban is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

Rivaroxaban

US brand names:Xarelto

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Rivaroxaban is dosed at 1–2 mg/kg PO q24h in dogs, per Swann JW, Garden OA, Fellman CL, et al. ACVIM consensus statement on the treatment of immune-mediated hemolytic anemia in dogs. J Vet Intern Med. 2019;33(3):1141-1172. doi:10.1111/jvim.15463; Blais MC, Bianco D, Goggs R, et al. Consensus on the rational use of antithrombotics in veterinary critical care (CURATIVE): domain 3-defining antithrombotic protocols. J Vet Emerg Crit Care. 2019;29(1):60-74. doi:10.1111/vec.12795 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1150 (2026-08-01).. Verify against current literature before clinical use.

Drug Class

Cardiovascular

Routes

Indications

Arterial thromboembolism preventionThromboembolism prevention

Mechanism of Action

Direct, selective factor Xa inhibitor that blocks the conversion of prothrombin to thrombin, preventing fibrin clot formation.

Side effects & warnings

Bleeding risk. No reliable reversal agent in veterinary practice. Monitor for occult bleeding. Limited canine pharmacokinetic data.

Species with Rivaroxaban dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugs All Dog (Domestic) drugs

Evidence levels across 2 dose rules

Weak×1Extrapolated×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published sources

· Corroborated 2026-07-31: Guillaumin J. J Feline Med Surg 2024;26(6):1098612X241257878. doi:10.1177/1098612X241257878 PMID:38857617 - cat, rivaroxaban 0.5-1 mg/kg PO q24h (review dose table; up to 2.5 mg PO q24h published).
· Swann JW, Garden OA, Fellman CL, et al. ACVIM consensus statement on the treatment of immune-mediated hemolytic anemia in dogs. J Vet Intern Med. 2019;33(3):1141-1172. doi:10.1111/jvim.15463; Blais MC, Bianco D, Goggs R, et al. Consensus on the rational use of antithrombotics in veterinary critical care (CURATIVE): domain 3-defining antithrombotic protocols. J Vet Emerg Crit Care. 2019;29(1):60-74. doi:10.1111/vec.12795 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1150 (2026-08-01).

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	1–2 mg/kg	q24h	Weak	Swann JW, Garden OA, Fellman CL, et al. ACVIM consensus statement on the treatment of immune-mediated hemolytic anemia in dogs. J Vet Intern Med. 2019;33(3):1141-1172. doi:10.1111/jvim.15463; Blais MC, Bianco D, Goggs R, et al. Consensus on the rational use of antithrombotics in veterinary critical care (CURATIVE): domain 3-defining antithrombotic protocols. J Vet Emerg Crit Care. 2019;29(1):60-74. doi:10.1111/vec.12795 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1150 (2026-08-01).
Cat (Domestic)	PO	1–2 mg/kg	q24h	Extrapolated

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