Pocket Pet · Cavia porcellus · typical adult weight 0.70–1.20 kg
S-Adenosylmethionine is dosed at 20–100 mg/kg PO q24h in guinea pigs, per Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.802 (2026-08-01, PENDING REVIEW). S-Adenosylmethionine is used in guinea pigs for Hepatic support. Routes documented in guinea pigs: PO. A typical adult guinea pig weighs 0.70–1.20 kg. ExoticRx lists 1 cited dose rule for S-Adenosylmethionine in guinea pigs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Denosyl, SAMe
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| PO | 20–100 mg/kg | q24h | Hepatic support | Weak | Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.802 (2026-08-01, PENDING REVIEW) |
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These ranges are per kg. Enter your guinea pig's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Methyl donor and precursor to glutathione synthesis. Supports hepatocellular glutathione levels, membrane fluidity, and antioxidant defense. Also has anti-inflammatory properties.
Give on empty stomach (food reduces absorption by 70%). Enteric coating must not be broken. Well-tolerated. Used for hepatic support and as antioxidant. Not a substitute for specific hepatic therapy.
Species-specific contraindications and adverse-reaction reports for guinea pigs may differ from canine / feline reference data — consult the primary citations listed with each rule.
S-Adenosylmethionine dose range in guinea pigs, with cited source references: PO 20–100 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for S-Adenosylmethionine in guinea pigs: PO.
S-Adenosylmethionine is indicated in guinea pigs for: Hepatic support.
These are general warnings for S-Adenosylmethionine across species; consult the guinea pig dosing table above for species-specific guidance. Give on empty stomach (food reduces absorption by 70%). Enteric coating must not be broken. Well-tolerated. Used for hepatic support and as antioxidant. Not a substitute for specific hepatic therapy.
Why a species-specific page? S-Adenosylmethionine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in guinea pigs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.