Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
S-Adenosylmethionine is dosed at 20 mg/kg PO q24h in dogs, per Webster CRL, Center SA, Cullen JM, et al. ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs. Journal of Veterinary Internal Medicine. 2019;33:1173-1200. doi:10.1111/jvim.15467 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1166 (2026-08-01).. S-Adenosylmethionine is used in dogs for Hepatic support, antioxidant, Hepatoprotection. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for S-Adenosylmethionine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Denosyl, SAMe
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 20 mg/kg | q24h | Long-term | Hepatic support, antioxidant | Moderate | Webster CRL, Center SA, Cullen JM, et al. ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs. Journal of Veterinary Internal Medicine. 2019;33:1173-1200. doi:10.1111/jvim.15467 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1166 (2026-08-01). |
| PO | 20–40 mg/kg | q24h on empty stomach | Long-term | Hepatoprotection | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed, S-Adenosyl-Methionine (SAMe)/Silybin, p.1168 (printed p.1141) |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Methyl donor and precursor to glutathione synthesis. Supports hepatocellular glutathione levels, membrane fluidity, and antioxidant defense. Also has anti-inflammatory properties.
Give on empty stomach (food reduces absorption by 70%). Enteric coating must not be broken. Well-tolerated. Used for hepatic support and as antioxidant. Not a substitute for specific hepatic therapy.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
S-Adenosylmethionine dose ranges in dogs, with cited source references: PO 20 mg/kg q24h; PO 20–40 mg/kg q24h on empty stomach. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for S-Adenosylmethionine in dogs: PO.
Cited course lengths for S-Adenosylmethionine in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
S-Adenosylmethionine is indicated in dogs for: Hepatic support, antioxidant, Hepatoprotection.
These are general warnings for S-Adenosylmethionine across species; consult the dog dosing table above for species-specific guidance. Give on empty stomach (food reduces absorption by 70%). Enteric coating must not be broken. Well-tolerated. Used for hepatic support and as antioxidant. Not a substitute for specific hepatic therapy.
Why a species-specific page? S-Adenosylmethionine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.