Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
S-Adenosylmethionine is used in dog for Hepatic support, antioxidant, Hepatoprotection. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for S-Adenosylmethionine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Denosyl, SAMe
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Methyl donor and precursor to glutathione synthesis. Supports hepatocellular glutathione levels, membrane fluidity, and antioxidant defense. Also has anti-inflammatory properties.
Give on empty stomach (food reduces absorption by 70%). Enteric coating must not be broken. Well-tolerated. Used for hepatic support and as antioxidant. Not a substitute for specific hepatic therapy.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? S-Adenosylmethionine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.