ExoticRx · exoticrx.com/drugs/s-adenosylmethionine
US brand names:Denosyl, SAMe
S-Adenosylmethionine is dosed at 20–100 mg/kg PO q24h in guinea pigs, per Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.802 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.7 (Miscellaneous Agents Used in Rodents). Verify against current literature before clinical use.
Methyl donor and precursor to glutathione synthesis. Supports hepatocellular glutathione levels, membrane fluidity, and antioxidant defense. Also has anti-inflammatory properties.
Give on empty stomach (food reduces absorption by 70%). Enteric coating must not be broken. Well-tolerated. Used for hepatic support and as antioxidant. Not a substitute for specific hepatic therapy.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Dwarf Hamster drugsAll Ferret drugsAll Guinea Pig drugsAll Pet Rat drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 6 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | PO | 20 mg/kg | q24h | Moderate | Center S. Update on Canine & Feline Liver Disease. Presented at: ECVIM; 2008. — Plumb's Veterinary Drug Handbook, 10th Ed, p.1139Compilation only — we have not located an independent source that prints this figure. |
| Dog (Domestic) | PO | 20 mg/kg | q24h | Moderate | Webster CRL, Center SA, Cullen JM, et al. ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs. Journal of Veterinary Internal Medicine. 2019;33:1173-1200. doi:10.1111/jvim.15467 — Plumb's Veterinary Drug Handbook, 10th Ed, p.1139 |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.