ExoticRx · exoticrx.com/drugs/s-adenosylmethionine
US brand names:Denosyl, SAMe
S-Adenosylmethionine is dosed at 20–100 mg/kg PO q24h in dwarf hamsters, per 122. Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.802 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.7 (Miscellaneous Agents Used in Rodents). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: BSAVA Small Animal Formulary, Part B — Exotic Pets — ISBN 9781910443712, https://openlibrary.org/isbn/9781910443712; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.
Methyl donor and precursor to glutathione synthesis. Supports hepatocellular glutathione levels, membrane fluidity, and antioxidant defense. Also has anti-inflammatory properties.
Give on empty stomach (food reduces absorption by 70%). Enteric coating must not be broken. Well-tolerated. Used for hepatic support and as antioxidant. Not a substitute for specific hepatic therapy.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Dwarf Hamster drugsAll Ferret drugsAll Guinea Pig drugsAll Pet Rat drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 6 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | PO | 20 mg/kg | q24h | Moderate | Center S. Update on Canine & Feline Liver Disease. Presented at: ECVIM; 2008. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1166 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.1166' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.1139; verified by finding the drug named there. If you are holding the book, turn to p.1139. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Dog (Domestic) | PO | 20 mg/kg | q24h | Moderate | Webster CRL, Center SA, Cullen JM, et al. ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs. Journal of Veterinary Internal Medicine. 2019;33:1173-1200. doi:10.1111/jvim.15467 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1166 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.1166' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.1139; verified by finding the drug named there. If you are holding the book, turn to p.1139. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.