ExoticRx · exoticrx.com/drugs/s-adenosylmethionine
US brand names:Denosyl, SAMe
S-Adenosylmethionine is dosed at 20–40 mg/kg PO q24h on empty stomach in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Methyl donor and precursor to glutathione synthesis. Supports hepatocellular glutathione levels, membrane fluidity, and antioxidant defense. Also has anti-inflammatory properties.
Give on empty stomach (food reduces absorption by 70%). Enteric coating must not be broken. Well-tolerated. Used for hepatic support and as antioxidant. Not a substitute for specific hepatic therapy.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.