Cat · Felis catus · typical adult weight 2.50–7.00 kg
S-Adenosylmethionine is dosed at 20–40 mg/kg PO q24h on empty stomach in cats, per Plumb's Veterinary Drug Handbook, 9th Ed. S-Adenosylmethionine is used in cats for Hepatoprotection, cognitive dysfunction, Hepatic support. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 2 cited dose rules for S-Adenosylmethionine in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Denosyl, SAMe
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 20–40 mg/kg | q24h on empty stomach | Long-term | Hepatoprotection, cognitive dysfunction | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 20 mg/kg | q24h | Long-term | Hepatic support | Moderate | Center S. Update on Canine & Feline Liver Disease. Presented at: ECVIM; 2008. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1166 (2026-08-01). |
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Methyl donor and precursor to glutathione synthesis. Supports hepatocellular glutathione levels, membrane fluidity, and antioxidant defense. Also has anti-inflammatory properties.
Give on empty stomach (food reduces absorption by 70%). Enteric coating must not be broken. Well-tolerated. Used for hepatic support and as antioxidant. Not a substitute for specific hepatic therapy.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
S-Adenosylmethionine dose ranges in cats, with cited source references: PO 20–40 mg/kg q24h on empty stomach; PO 20 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for S-Adenosylmethionine in cats: PO.
Cited course lengths for S-Adenosylmethionine in cats include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
S-Adenosylmethionine is indicated in cats for: Hepatoprotection, cognitive dysfunction, Hepatic support.
These are general warnings for S-Adenosylmethionine across species; consult the cat dosing table above for species-specific guidance. Give on empty stomach (food reduces absorption by 70%). Enteric coating must not be broken. Well-tolerated. Used for hepatic support and as antioxidant. Not a substitute for specific hepatic therapy.
Why a species-specific page? S-Adenosylmethionine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.