Cat · Felis catus · typical adult weight 2.50–7.00 kg
S-Adenosylmethionine is dosed at 20 mg/kg PO q24h in cats, per Center S. Update on Canine & Feline Liver Disease. Presented at: ECVIM; 2008. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1166 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.1166' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.1139; verified by finding the drug named there. If you are holding the book, turn to p.1139. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. S-Adenosylmethionine is used in cats for Hepatic support. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for S-Adenosylmethionine in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Denosyl, SAMe
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 20 mg/kg | q24h | Long-term | Hepatic support | Moderate | Center S. Update on Canine & Feline Liver Disease. Presented at: ECVIM; 2008. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1166 (2026-08-01). — LOCATOR CONVENTION 2026-08-07: the bare 'p.1166' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.1139; verified by finding the drug named there. If you are holding the book, turn to p.1139. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/animal) | Route | Source | As printed |
|---|---|---|---|
| 90 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.748 | • 90 mg/cat/day PO up to 5 kg body weight. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Methyl donor and precursor to glutathione synthesis. Supports hepatocellular glutathione levels, membrane fluidity, and antioxidant defense. Also has anti-inflammatory properties.
Give on empty stomach (food reduces absorption by 70%). Enteric coating must not be broken. Well-tolerated. Used for hepatic support and as antioxidant. Not a substitute for specific hepatic therapy.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
S-Adenosylmethionine dose range in cats, with cited source references: PO 20 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for S-Adenosylmethionine in cats: PO.
Cited course lengths for S-Adenosylmethionine in cats include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
S-Adenosylmethionine is indicated in cats for: Hepatic support.
These are general warnings for S-Adenosylmethionine across species; consult the cat dosing table above for species-specific guidance. Give on empty stomach (food reduces absorption by 70%). Enteric coating must not be broken. Well-tolerated. Used for hepatic support and as antioxidant. Not a substitute for specific hepatic therapy.
Why a species-specific page? S-Adenosylmethionine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.