ExoticRx · exoticrx.com/drugs/sertraline
US brand names:Zoloft
Sertraline is dosed at 0.5–1.5 mg/kg PO q24h in cats, per Ogata N, Dantas LM de S, Crowell-Davis SL. Chapter 8: Selective Serotonin Reuptake Inhibitors. 2nd ed. (Crowell-Davis SL, Murray TF, Dantas LM de S, eds.). John Wiley & Sons, Inc.; 2019. — Plumb's 10th ed printed p.1153, Sertraline monograph spanning p.1153-1154. Verify against current literature before clinical use.
Selective serotonin reuptake inhibitor with mild dopamine reuptake inhibition. Potent SSRI used for anxiety and compulsive disorders.
Used for separation anxiety, noise phobias, compulsive behaviors. 4-6 weeks for full effect. Serotonin syndrome risk. GI upset common initially. Do not use with MAO inhibitors.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | PO | 0.5–1.5 mg/kg | q24h | Moderate | Ogata N, Dantas LM de S, Crowell-Davis SL. Chapter 8: Selective Serotonin Reuptake Inhibitors. 2nd ed. (Crowell-Davis SL, Murray TF, Dantas LM de S, eds.). John Wiley & Sons, Inc.; 2019. — Plumb's 10th ed printed p.1153, Sertraline monograph spanning p.1153-1154.Compilation only — we have not located an independent source that prints this figure. |
| Dog (Domestic) | PO | 0.5–4 mg/kg | q24h | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023), Sertraline, p.1181 (printed p.1154); corroborated by Crowell-Davis, Murray & Dantas, Veterinary Psychopharmacology 2nd ed, Table 8.1 printed p.105 — Plumb's 10th ed printed p.1154, Sertraline monograph spanning p.1153-1154.Compilation only — we have not located an independent source that prints this figure. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.