Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Sertraline is dosed at 0.5–4 mg/kg PO q24h in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), Sertraline, p.1181 (printed p.1154); corroborated by Crowell-Davis, Murray & Dantas, Veterinary Psychopharmacology 2nd ed, Table 8.1 printed p.105 (corpus PDF p.133) — Plumb's 10th ed (held) printed p.1154, Sertraline monograph spanning p.1153-1154; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Veterinary Psychopharmacology (Crowell-Davis) — ISBN 9781119226246, https://openlibrary.org/isbn/9781119226246. Sertraline is used in dogs for Separation anxiety, compulsive disorders. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Sertraline in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zoloft
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–4 mg/kg | q24h | Weeks to months | Separation anxiety, compulsive disorders | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), Sertraline, p.1181 (printed p.1154); corroborated by Crowell-Davis, Murray & Dantas, Veterinary Psychopharmacology 2nd ed, Table 8.1 printed p.105 (corpus PDF p.133) — Plumb's 10th ed (held) printed p.1154, Sertraline monograph spanning p.1153-1154; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Veterinary Psychopharmacology (Crowell-Davis) — ISBN 9781119226246, https://openlibrary.org/isbn/9781119226246 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 1–3 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.389 | 1-3 mg/kg p.o. q24h, although higher doses are described in the literature |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Selective serotonin reuptake inhibitor with mild dopamine reuptake inhibition. Potent SSRI used for anxiety and compulsive disorders.
Used for separation anxiety, noise phobias, compulsive behaviors. 4-6 weeks for full effect. Serotonin syndrome risk. GI upset common initially. Do not use with MAO inhibitors.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Sertraline dose range in dogs, with cited source references: PO 0.5–4 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Sertraline in dogs: PO.
Cited course lengths for Sertraline in dogs include: Weeks to months. Duration depends on the indication — match it to the specific dose rule in the table above.
Sertraline is indicated in dogs for: Separation anxiety, compulsive disorders.
These are general warnings for Sertraline across species; consult the dog dosing table above for species-specific guidance. Used for separation anxiety, noise phobias, compulsive behaviors. 4-6 weeks for full effect. Serotonin syndrome risk. GI upset common initially. Do not use with MAO inhibitors.
Why a species-specific page? Sertraline pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.