ExoticRx · exoticrx.com/drugs/sodium-nitrite
US brand names:Nithiodote(component)
Sodium Nitrite is dosed at 10–20 mg/kg IV Single slow IV dose in dogs, per Hoareau G. Smoke inhalation. Presented at: Pacific Veterinary Conferences; 2016. — Plumb's Veterinary Drug Handbook, 10th Ed, p.1166. Verify against current literature before clinical use.
Oxidizes hemoglobin to methemoglobin, which has high affinity for cyanide, forming cyanmethemoglobin and freeing cytochrome oxidase. Combined with sodium thiosulfate.
Creates controlled methemoglobinemia — dangerous if overdosed. Monitor methemoglobin levels. Do not use in smoke inhalation (already elevated carboxyhemoglobin).
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 10–20 mg/kg | Single slow IV dose | Moderate | Hoareau G. Smoke inhalation. Presented at: Pacific Veterinary Conferences; 2016. — Plumb's Veterinary Drug Handbook, 10th Ed, p.1166Compilation only — we have not located an independent source that prints this figure. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.