ExoticRx · exoticrx.com/drugs/sodium-thiosulfate
US brand names:Nithiodote
Sodium Thiosulfate is dosed at 250–500 mg/kg IV Single IV dose over 10-20 minutes in dogs, per Hoareau G. Smoke inhalation. Presented at: Pacific Veterinary Conferences; 2016. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1193 (2026-08-01).. Verify against current literature before clinical use.
Provides sulfur substrate for rhodanese enzyme to convert cyanide to thiocyanate, which is renally excreted. Also used topically for cisplatin extravasation.
IV route for cyanide poisoning. Large volume bolus — infuse over 10-20 minutes. Often combined with sodium nitrite or hydroxocobalamin. Low toxicity.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 250–500 mg/kg | Single IV dose over 10-20 minutes | Moderate | Hoareau G. Smoke inhalation. Presented at: Pacific Veterinary Conferences; 2016. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1193 (2026-08-01). |
| Cat (Domestic) | IV | 250–500 mg/kg | Single IV dose | Weak | Hoareau G. Smoke inhalation. Presented at: Pacific Veterinary Conferences; 2016. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1193 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.