Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Sodium Thiosulfate is dosed at 250–500 mg/kg IV Single IV dose over 10-20 minutes in dogs, per Hoareau G. Smoke inhalation. Presented at: Pacific Veterinary Conferences; 2016. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1193 (2026-08-01).. Sodium Thiosulfate is used in dogs for Cyanide poisoning. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Sodium Thiosulfate in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Nithiodote
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 250–500 mg/kg | Single IV dose over 10-20 minutes | Single dose; may repeat at 50% dose in 30-60 min if needed | Cyanide poisoning | Moderate | Hoareau G. Smoke inhalation. Presented at: Pacific Veterinary Conferences; 2016. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1193 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Provides sulfur substrate for rhodanese enzyme to convert cyanide to thiocyanate, which is renally excreted. Also used topically for cisplatin extravasation.
IV route for cyanide poisoning. Large volume bolus — infuse over 10-20 minutes. Often combined with sodium nitrite or hydroxocobalamin. Low toxicity.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Sodium Thiosulfate dose range in dogs, with cited source references: IV 250–500 mg/kg Single IV dose over 10-20 minutes. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Sodium Thiosulfate in dogs: IV.
Cited course lengths for Sodium Thiosulfate in dogs include: Single dose; may repeat at 50% dose in 30-60 min if needed. Duration depends on the indication — match it to the specific dose rule in the table above.
Sodium Thiosulfate is indicated in dogs for: Cyanide poisoning.
These are general warnings for Sodium Thiosulfate across species; consult the dog dosing table above for species-specific guidance. IV route for cyanide poisoning. Large volume bolus — infuse over 10-20 minutes. Often combined with sodium nitrite or hydroxocobalamin. Low toxicity.
Why a species-specific page? Sodium Thiosulfate pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.