Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Sodium Thiosulfate is used in dog for Cyanide poisoning. Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Sodium Thiosulfate in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Nithiodote
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 250–500 mg/kg | Single IV dose over 10-20 minutes | Single dose; may repeat at 50% dose in 30-60 min if needed | Cyanide poisoning | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Provides sulfur substrate for rhodanese enzyme to convert cyanide to thiocyanate, which is renally excreted. Also used topically for cisplatin extravasation.
IV route for cyanide poisoning. Large volume bolus — infuse over 10-20 minutes. Often combined with sodium nitrite or hydroxocobalamin. Low toxicity.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Sodium Thiosulfate pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.