Livestock · Sus scrofa domesticus · typical adult weight 1.00–300.00 kg
Tylosin is dosed at 4.4–8.8 mg/kg IM q24h in swine, per FDA NADA 012-491 — TYLAN 100 (TYLOSIN PHOSPHATE) GRANULE [ELANCO US INC.] — https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0cb546ce-5db1-47a7-85b0-b6800ecb3315 NOTE: this label doses in g/lb, mg/head, not mg/kg; the served figure is a unit conversion and is NOT printed verbatim on the label. Label dosing: '100 g per lb Ingredients: Roughage products, calcium carbonate and mineral oil.' — 21 CFR § 522.2640 (Tylosin), conditions of use for Swine: 8.8185-8.8185 mg/kg (the regulation prints this per pound; converted at 2.2046226 lb/kg). Related tolerances: 21 CFR § 556.746. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-522.2640 | mg/kg BASIS LOCATED 2026-08-19: Papich, Saunders Handbook of Veterinary Drugs, p.855, "Large Animal Dosage - Swine - Treatment of arthritis, erysipelas, and swine dysentery: 8.8 mg/kg q12h IM." The served 8.8 mg/kg IM is printed for this species in this unit; it is not only a conversion off the feed label. Book interval is q12h; this rule serves q24h.. Tylosin is used in swine for Swine dysentery, pneumonia, arthritis. Routes documented in swine: IM. A typical adult swine weighs 1.00–300.00 kg. ExoticRx lists 1 cited dose rule for Tylosin in swine, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Tylan
Contraindicated in Horse (Equine)
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 4.4–8.8 mg/kg | q24h | 3-5 days | Swine dysentery, pneumonia, arthritis | Weak | FDA NADA 012-491 — TYLAN 100 (TYLOSIN PHOSPHATE) GRANULE [ELANCO US INC.] — https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0cb546ce-5db1-47a7-85b0-b6800ecb3315 NOTE: this label doses in g/lb, mg/head, not mg/kg; the served figure is a unit conversion and is NOT printed verbatim on the label. Label dosing: '100 g per lb Ingredients: Roughage products, calcium carbonate and mineral oil.' — 21 CFR § 522.2640 (Tylosin), conditions of use for Swine: 8.8185-8.8185 mg/kg (the regulation prints this per pound; converted at 2.2046226 lb/kg). Related tolerances: 21 CFR § 556.746. Retrieved from the eCFR API, snapshot 2026-01-01. https://www.ecfr.gov/current/title-21/section-522.2640 | mg/kg BASIS LOCATED 2026-08-19: Papich, Saunders Handbook of Veterinary Drugs, p.855, "Large Animal Dosage - Swine - Treatment of arthritis, erysipelas, and swine dysentery: 8.8 mg/kg q12h IM." The served 8.8 mg/kg IM is printed for this species in this unit; it is not only a conversion off the feed label. Book interval is q12h; this rule serves q24h. |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 8.8 | IM | Papich Saunders Handbook of Veterinary Drugs, 4th edp.855 | • Treatment of arthritis, erysipelas, and swine dysentery: 8.8 mg/kg q12h IM. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Binds 50S ribosomal subunit, inhibiting bacterial protein synthesis. Anti-inflammatory properties in GI tract.
CONTRAINDICATED in rabbits, guinea pigs (fatal dysbiosis). Commonly used for chronic colitis in dogs. Very bitter taste. IM injection painful.
Species-specific contraindications and adverse-reaction reports for swine may differ from canine / feline reference data — consult the primary citations listed with each rule.
Tylosin dose range in swine, with cited source references: IM 4.4–8.8 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Tylosin in swine: IM.
Cited course lengths for Tylosin in swine include: 3-5 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Tylosin is indicated in swine for: Swine dysentery, pneumonia, arthritis.
These are general warnings for Tylosin across species; consult the swine dosing table above for species-specific guidance. CONTRAINDICATED in rabbits, guinea pigs (fatal dysbiosis). Commonly used for chronic colitis in dogs. Very bitter taste. IM injection painful.
Why a species-specific page? Tylosin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in swine — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.