ExoticRx · exoticrx.com/drugs/tylosin
US brand names:Tylan
Tylosin is dosed at 5 mg/kg IM q 24 h in russian tortoises, per Divers SJ. Empirical doses of antimicrobial drugs commonly used in reptiles. Exot DVM. 1998;1:23. — Verified against Mader's Reptile and Amphibian Medicine and Surgery, 3rd Ed, p.1404 (2026-08-01).. Verify against current literature before clinical use.
Binds 50S ribosomal subunit, inhibiting bacterial protein synthesis. Anti-inflammatory properties in GI tract.
CONTRAINDICATED in rabbits, guinea pigs (fatal dysbiosis). Commonly used for chronic colitis in dogs. Very bitter taste. IM injection painful.
Species references:All African Grey Parrot drugsAll Cattle (Beef/Dairy) drugsAll Chicken (Poultry) drugsAll Dog (Domestic) drugsAll Russian Tortoise drugsAll Swine (Pig) drugsAll Turkey drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 7 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IM | 8–11 mg/kg | q12h | Moderate | Papich Saunders Handbook of Veterinary Drugs 4th ed., Tylosin, Small Animal Dosage > Dogs, printed p.827 (corpus p.855) |
| Dog (Domestic) | PO | 5–15 mg/kg | q8-12h | Moderate | Simpson KW, Manchester A c. Chapter 134: Canine Colitis. In: Bonagura JD, Twedt DC, eds. Current Veterinary Therapy XV. Elsevier Saunders; 2014:550-553. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1312 (2026-08-01). |
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