What is Tylosin GI used for?

Tylosin GI is indicated for: Chronic diarrhea, Chronic diarrhea (tylosin-responsive diarrhea).

Which species have cited Tylosin GI dosing data?

Tylosin GI dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Is Tylosin GI a controlled substance?

Tylosin GI is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

Tylosin GI

US brand names:Tylan Powder

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Tylosin GI is dosed at 10–25 mg/kg PO q12h in dogs, per Hall EJ. Antibiotic-responsive diarrhea in small animals. Vet Clin North Am Small Animal Pract. 2011;41(2):273-286. doi:10.1016/j.cvsm.2010.12.004; Weese JS. Bacterial enteritis in dogs and cats: diagnosis, therapy, and zoonotic potential. Vet Clin North Am Small Animal Pract. 2011;41(2):287-309. doi:10.1016/j.cvsm.2010.12.005 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1312 (2026-08-01).. Verify against current literature before clinical use.

Drug Class

Gastrointestinal

Routes

Indications

Chronic diarrhea

Mechanism of Action

Macrolide antibiotic with anti-inflammatory and immunomodulatory effects on GI mucosa. Mechanism for GI benefit not fully understood — may modify gut flora.

Side effects & warnings

Widely used for chronic diarrhea in dogs responsive to tylosin. Very bitter — mix well with food. Long-term use common. Relapse on discontinuation typical.

Evidence levels across 2 dose rules

Strong×1Moderate×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published sources

· Hall EJ. Antibiotic-responsive diarrhea in small animals. Vet Clin North Am Small Animal Pract. 2011;41(2):273-286. doi:10.1016/j.cvsm.2010.12.004; Weese JS. Bacterial enteritis in dogs and cats: diagnosis, therapy, and zoonotic potential. Vet Clin North Am Small Animal Pract. 2011;41(2):287-309. doi:10.1016/j.cvsm.2010.12.005 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1312 (2026-08-01).
· Lappin MR. Diagnosis and treatment of cryptosporidium and isospora in cats. Presented at: World Small Animal Veterinary Association World Congress; 2011.; Weese JS. Bacterial enteritis in dogs and cats: diagnosis, therapy, and zoonotic potential. Vet Clin North Am Small Animal Pract. 2011;41(2):287-309. doi:10.1016/j.cvsm.2010.12.005 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1313 (2026-08-01).

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	10–25 mg/kg	q12h	Strong	Hall EJ. Antibiotic-responsive diarrhea in small animals. Vet Clin North Am Small Animal Pract. 2011;41(2):273-286. doi:10.1016/j.cvsm.2010.12.004; Weese JS. Bacterial enteritis in dogs and cats: diagnosis, therapy, and zoonotic potential. Vet Clin North Am Small Animal Pract. 2011;41(2):287-309. doi:10.1016/j.cvsm.2010.12.005 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1312 (2026-08-01).
Cat (Domestic)	PO	5–10 mg/kg	q12h	Moderate	Lappin MR. Diagnosis and treatment of cryptosporidium and isospora in cats. Presented at: World Small Animal Veterinary Association World Congress; 2011.; Weese JS. Bacterial enteritis in dogs and cats: diagnosis, therapy, and zoonotic potential. Vet Clin North Am Small Animal Pract. 2011;41(2):287-309. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1313 (2026-08-01).

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