Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Tylosin GI is dosed at 10–25 mg/kg PO q12h in dogs, per Hall EJ. Antibiotic-responsive diarrhea in small animals. Vet Clin North Am Small Animal Pract. 2011;41(2):273-286. doi:10.1016/j.cvsm.2010.12.004; Weese JS. Bacterial enteritis in dogs and cats: diagnosis, therapy, and zoonotic potential. Vet Clin North Am Small Animal Pract. 2011;41(2):287-309. doi:10.1016/j.cvsm.2010.12.005 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1312 (2026-08-01). — Plumb's 10th ed (held) printed p.1284, Tylosin monograph spanning p.1284-1286; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Tylosin GI is used in dogs for Chronic diarrhea (tylosin-responsive diarrhea). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Tylosin GI in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Tylan Powder
Contraindicated in Horse (Equine)
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 10–25 mg/kg | q12h | Long-term | Chronic diarrhea (tylosin-responsive diarrhea) | Strong | Hall EJ. Antibiotic-responsive diarrhea in small animals. Vet Clin North Am Small Animal Pract. 2011;41(2):273-286. doi:10.1016/j.cvsm.2010.12.004; Weese JS. Bacterial enteritis in dogs and cats: diagnosis, therapy, and zoonotic potential. Vet Clin North Am Small Animal Pract. 2011;41(2):287-309. doi:10.1016/j.cvsm.2010.12.005 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1312 (2026-08-01). — Plumb's 10th ed (held) printed p.1284, Tylosin monograph spanning p.1284-1286; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 7–15 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.436 | 7-15 mg/kg p.o. q12-24h. In colitis, higher doses recommended 12-20 mg/kg q8h with food gradua |
| 12–20 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.436 | kg p.o. q12-24h. In colitis, higher doses recommended 12-20 mg/kg q8h with food gradually increasing the dosing interval to q24h |
| 7–15 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.855 | • 7-15 mg/kg q12-24h PO. |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Macrolide antibiotic with anti-inflammatory and immunomodulatory effects on GI mucosa. Mechanism for GI benefit not fully understood — may modify gut flora.
Widely used for chronic diarrhea in dogs responsive to tylosin. Very bitter — mix well with food. Long-term use common. Relapse on discontinuation typical.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Tylosin GI dose range in dogs, with cited source references: PO 10–25 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Tylosin GI in dogs: PO.
Cited course lengths for Tylosin GI in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Tylosin GI is indicated in dogs for: Chronic diarrhea (tylosin-responsive diarrhea).
These are general warnings for Tylosin GI across species; consult the dog dosing table above for species-specific guidance. Widely used for chronic diarrhea in dogs responsive to tylosin. Very bitter — mix well with food. Long-term use common. Relapse on discontinuation typical.
Why a species-specific page? Tylosin GI pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 8–11 |
| IM |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.855 |
| • 8-11 mg/kg q12h IM. |
| 12–20 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.855 | • Colitis: 12-20 mg/kg q8h with food, then if there is a response, increase the interval |
| 20 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.855 | to q12h and eventually to q24h. (20 mg/kg is approximately 1/8 teaspoon of |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.