ExoticRx · exoticrx.com/drugs/unoprostone-ophthalmic
US brand names:Rescula
Docosanoid prostaglandin analogue that increases uveoscleral and trabecular outflow. Less potent than latanoprost but may cause less inflammation in uveitis-prone eyes.
Milder IOP reduction than other prostaglandin analogues. May be better tolerated in eyes with prior uveitis. BID dosing (vs QD for other PGAs). Limited veterinary data.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | Ophthalmic | Less potent IOP reduction than latanoprost but may cause less uveitis | 1 drop affected eye q12h | Weak | Gelatt, K.N. & MacKay, E.O. (2001a); Ofri, R., et al. (2000) - cited in Gelatt, Veterinary Ophthalmology 6th ed., 8.5 Clinical Pharmacology and Therapeutics — Verified against Veterinary Ophthalmology (Gelatt), 6th Ed, p.486 (2026-08-01). |
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