Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Ammonium Chloride is dosed at 100 mg/kg PO q12h in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), Ammonium Chloride, printed p.66 (corpus plumb p.93); corroborated by Papich, Saunders Handbook of Veterinary Drugs, 5th Ed, p.37 (corpus papich p.65): 'Dogs: 100 mg/kg q12h PO' — EDITION UNVERIFIABLE 2026-08-07: this citation names Papich 5th ed, which is NOT held. Its page locator does not resolve to a page naming this drug in the held 4th ed (2016), so the reference cannot be confirmed against any copy available here. Treat the page number as unchecked and consult the 5th edition directly. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855. Ammonium Chloride is used in dogs for Struvite dissolution (urinary acidification). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Ammonium Chloride in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 100 mg/kg | q12h | Until struvites dissolved | Struvite dissolution (urinary acidification) | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), Ammonium Chloride, printed p.66 (corpus plumb p.93); corroborated by Papich, Saunders Handbook of Veterinary Drugs, 5th Ed, p.37 (corpus papich p.65): 'Dogs: 100 mg/kg q12h PO' — EDITION UNVERIFIABLE 2026-08-07: this citation names Papich 5th ed, which is NOT held. Its page locator does not resolve to a page naming this drug in the held 4th ed (2016), so the reference cannot be confirmed against any copy available here. Treat the page number as unchecked and consult the 5th edition directly. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Saunders Handbook of Veterinary Drugs — ISBN 9780323244855, https://openlibrary.org/isbn/9780323244855 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/animal) | Route | Source | As printed |
|---|---|---|---|
| 800 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.65 | • 100 mg/kg q12h PO. • 800 mg/cat, or 20 mg/kg (approxi- |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 100 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.65 | • 100 mg/kg q12h PO. • 800 mg/cat, or 20 mg/kg (approxi- |
| 20 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.65 | • 100 mg/kg q12h PO. • 800 mg/cat, or 20 mg/kg (approxi- |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Metabolized by liver releasing HCl and producing systemic acidification. Excreted renally as acidifying ammonium ion.
Used for metabolic alkalosis and struvite urolith prevention/dissolution. Contraindicated in hepatic insufficiency (ammonia cannot be metabolized). Monitor blood pH and electrolytes.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ammonium Chloride dose range in dogs, with cited source references: PO 100 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ammonium Chloride in dogs: PO.
Cited course lengths for Ammonium Chloride in dogs include: Until struvites dissolved. Duration depends on the indication — match it to the specific dose rule in the table above.
Ammonium Chloride is indicated in dogs for: Struvite dissolution (urinary acidification).
These are general warnings for Ammonium Chloride across species; consult the dog dosing table above for species-specific guidance. Used for metabolic alkalosis and struvite urolith prevention/dissolution. Contraindicated in hepatic insufficiency (ammonia cannot be metabolized). Monitor blood pH and electrolytes.
Why a species-specific page? Ammonium Chloride pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.