Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Diazoxide is dosed at 5–30 mg/kg PO q12h in dogs, per Nelson RW. Chapter 9: Beta-Cell Neoplasia: Insulinoma. In: Feldman EC, Nelson RW, Reusch CE, Scott-Moncrieff JCR, Behrend EN, eds. Canine and Feline Endocrinology. 4th ed. Elsevier Saunders; 2015:348-375. doi:10.1016/b978-1-4557-4456-5.00009-2 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.410 (2026-08-01). — Plumb's 10th ed (held) printed p.382, Diazoxide monograph spanning p.382-383; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Diazoxide is used in dogs for Insulinoma (medical management). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Diazoxide in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Proglycem
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–30 mg/kg | q12h | Long-term | Insulinoma (medical management) | Moderate | Nelson RW. Chapter 9: Beta-Cell Neoplasia: Insulinoma. In: Feldman EC, Nelson RW, Reusch CE, Scott-Moncrieff JCR, Behrend EN, eds. Canine and Feline Endocrinology. 4th ed. Elsevier Saunders; 2015:348-375. doi:10.1016/b978-1-4557-4456-5.00009-2 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.410 (2026-08-01). — Plumb's 10th ed (held) printed p.382, Diazoxide monograph spanning p.382-383; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 5 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.137 | 5 mg/kg p.o. q12h initially, increasing gradually to 30 mg/kg p.o. q12h. |
| 30 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.137 | 5 mg/kg p.o. q12h initially, increasing gradually to 30 mg/kg p.o. q12h. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Opens KATP channels in pancreatic beta cells, inhibiting insulin secretion. Also has extrapancreatic hyperglycemic effects.
Used for insulinoma management (dogs). GI upset, anorexia, hypotension. Sodium and fluid retention (may need diuretic). Monitor blood glucose. Expensive.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Diazoxide dose range in dogs, with cited source references: PO 5–30 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Diazoxide in dogs: PO.
Cited course lengths for Diazoxide in dogs include: Long-term. Duration depends on the indication — match it to the specific dose rule in the table above.
Diazoxide is indicated in dogs for: Insulinoma (medical management).
These are general warnings for Diazoxide across species; consult the dog dosing table above for species-specific guidance. Used for insulinoma management (dogs). GI upset, anorexia, hypotension. Sodium and fluid retention (may need diuretic). Monitor blood glucose. Expensive.
Why a species-specific page? Diazoxide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.